Data availability All raw data and the Mascot output tables have been deposited to iProX and can be accessed with the accession IPX00081900. Additional information How to cite this article:Zhou, Q.et al. A mouse tissue transcription factor atlas.Nat. Commun.8,15089 doi: 10.1038/ncomms15089 ...
Transcriptional regulation exhibits extensive robustness, but human genetics indicates sensitivity to transcription factor (TF) dosage. Reconciling such observations requires quantitative studies of TF dosage effects at trait-relevant ranges, largely lacking so far. TFs play central roles in both normal-rang...
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Transcription Factor 23 (TCF23) (C-Term) 抗体 公司简介 上海钰博生物科技有限公司是2012年5月由“海归”组成的创业团队与两个专业投资机构发起成立的,以开发生产科研试剂和特色检验产品为方向,经过两年多的努力,已经建立了免疫学和分子生物学的五个技术平台,开发了ELISA/ELISpot酶联免疫试剂盒、重组蛋白、荧光标记...
Human peripheral blood lymphocytes were surface stained with CD3 APC and then treated with True-Nuclear™ Transcription Factor Buffer Set. Cells were then stained with T-bet (clone 4B10) Brilliant Violet 421™ (top) or mouse IgG1, κ Brilliant Violet 421™ isotype control (bottom). ...
Modulators (Ms)2 are proteins that modify the activity of a transcription factor (TF). Modulators often act by binding directly to the TFs to affect the expression of a target gene. The outcome of modulation can be classified into the six possible action modes: inhibition attenuation, inhibition...
(d) Heatmap showing the distance of de novo motifs detected per iteration (columns) to the most similar database motif (row) for significant motifs from a simulated de novo run. To the left, the number of sites from the corresponding ChIP-seq run per factor is shown as a bar plot. ...
(uORFs) present in the 5′ UTR, resulting in low Gcn4 abundance. Upon amino acid starvation, the Gcn2 kinase phosphorylates the translation initiation factor eIF2α, leading to reduced levels of GTP-bound eIF2 and depletion of the ternary translation initiation complex. This allows the ...
抗体名:Thyroid transcription factor-1 (TTF1) mouse Monoclonal Antibody(PT2256) 宿主:Mouse/IgG2b, Kappa 用途:科研实验 应用范围:IHC-p 产地:中国 品牌:chemstan 货号:CS38682 用途:科研实验 保质期:一年 包装规格:100ul 保存条件:Stable for one year at -20°C ...
and biogrid database [ 23 ]; and those tf pairs which have the same known co-factor (trios) found in these databases [ 9 , 23 ] (figure 2 , red dots and orange triangles, respectively). however, the majority of these known interactions correspond to tf pairs with rather low ...