Transcription factor binding site analysis.Jörg BartelJan KrumsiekKatharina SchrammJerzy AdamskiChristian GiegerChristian HerderMaren CarstensenAnnette PetersWolfgang RathmannMichael Roden
Here, using a massively parallel reporter assay (MPRA) of 209,440 sequences, we examine all possible pair and triplet combinations, permutations and orientations of eighteen liver-associated transcription factor binding sites (TFBS). We find that TFBS orientation and order have a major effect on ...
A sequence motif is a short recurring pattern with biological significance such as a DNA-recognition sequence for a transcription factor (TF), an mRNA splicing signal, or a functional region of a protein domain. Many high-throughput experimental approaches and computational tools have been developed...
Second, the phrase may mean a collection of DNA sequences that conform to a common pattern (motif) and are specifically recognized by a common transcription factor. As individual binding sites for a given transcription factor are often very different, a motif is usually represented by a ...
Research into molecular mechanisms underlying DNA-protein interactions using statistical analysis of nucleotide sequences of binding sites is most important for understanding the principles of gene expression regulation. The local conformation of transcription factor binding sites determined by their context is...
MatInspector and beyond: promoter analysis based on transcription factor binding sites MOTIVATION: Promoter analysis is an essential step on the way to identify regulatory networks. A prerequisite for successful promoter analysis is the predi... K Cartharius,K Frech,K Grote,... - 《Bioinformatics...
必应词典为您提供Transcription-factor-binding-site的释义,网络释义: 转录因子的结合位点;转录因子结合位;基因调控子序列;
Binding of transcription factors to transcription factor binding sites (TFBSs) is key to the mediation of transcriptional regulation. Information on experimentally validated functional TFBSs is limited and consequently there is a need for accurate predic
Scientists routinely scan DNA sequences for transcription factor (TF) bindingsites (TFBSs). Most of the available tools rely on position-specific scoringmatrices (PSSMs) constructed from aligned binding sites. Because of theresolutions of assays used to
DNA sequence motif analysis We used the RTFBSdb suite40 that clusters transcription factor binding motifs based on similarity, chooses a representative motif for each cluster based on the expression data, and computes enrichment for known motifs. We filtered CIS-BP motifs based on expression in our...