定义:transcription factor binding site(TFBS) TFBS指的是TF特异结合的DNA分子的position(位置),延伸的话,就是DNA片段的序列边界。 注意,文献中经常把结合位点和结合域混淆(binding site ,binding motif) 我们推荐保留“site”这个词来定义某一特别sequence(基因的或artificial),这是一个factor结合的地方。而“motif”...
Transcription factor binding site (TFBS, transcription factor address site, transcription factor recognition element, transcription factor recognition site)doi:10.1002/9783527678679.dg13498John M. HancockJohn Wiley & Sons, Ltd
Second, the phrase may mean a collection of DNA sequences that conform to a common pattern (motif) and are specifically recognized by a common transcription factor. As individual binding sites for a given transcription factor are often very different, a motif is usually represented by a ...
We report that about 45% of all human small hairpin microRNA (pre-miR) sequences contain at least one predicted transcription factor binding site motif that is conserved across human, mouse and rat, and this rises to over 75% if one excludes primate-specific pre-miRs. The association is ro...
(2014). Transcription factor binding site mapping using ChIP-Seq. Microbiol. Spectr. 2:MGM2-0035-2013. doi: 10.1128/microbiolspec.MGM2-0035-2013Jaini S, Lyubetskaya A, Gomes A, et al. Transcription factor binding site mapping using ChIP-Seq. Microbiology Spectrum, 2014, 2(2): 1-21...
SOX5 NM_001261414.3 Human Homo sapiens SRY-box transcription factor 5 (SOX5), transcript variant 4, mRNA. 1929 GC-E1940 HSF1 NM_005526.4 Human Homo sapiens heat shock transcription factor 1 (HSF1), mRNA. 1590 GC-F0013 GATA2 NM_001145661.2 Human Homo sapiens GATA binding protein 2 (GATA...
Recently, deep learning based models have been proposed and have shown competitive results on a transcription factor binding site prediction task. However, it is difficult to interpret the prediction results obtained from the previous models. In addition, the previous models assumed all the sequence ...
A sequence motif is a short recurring pattern with biological significance such as a DNA-recognition sequence for a transcription factor (TF), an mRNA splicing signal, or a functional region of a protein domain. Many high-throughput experimental approaches and computational tools have been developed...
Context-dependent transcription factor (TF) binding is one reason for differences in gene expression patterns between different cellular states. Chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) identifies genome-wide TF bin
Gene expression is to large degree regulated by the specific binding of protein transcription factors to cis-regulatory transcription factor binding sites in gene promoter regions. Despite the identification of hundreds of binding site sequence motifs, t