定义:transcription factor binding site(TFBS) TFBS指的是TF特异结合的DNA分子的position(位置),延伸的话,就是DNA片段的序列边界。 注意,文献中经常把结合位点和结合域混淆(binding site ,binding motif) 我们推荐保留“site”这个词来定义某一特别sequence(基因的或artificial),这是一个factor结合的地方。而“motif”...
必应词典为您提供Transcription-factor-binding-site的释义,网络释义: 转录因子的结合位点;转录因子结合位;基因调控子序列;
Second, the phrase may mean a collection of DNA sequences that conform to a common pattern (motif) and are specifically recognized by a common transcription factor. As individual binding sites for a given transcription factor are often very different, a motif is usually represented by a ...
Transcription factor binding site orientation and order are major drivers of gene regulatory activity Ilias Georgakopoulos-Soares, Chengyu Deng, Vikram Agarwal, Candace S. Y. Chan, Jingjing Zhao, Fumitaka Inoue & Nadav Ahituv Nature Communications volume 14, Article number: 2333 (2023) ...
【transcription factor】意思是【转录因子】。【转录因子定义】转录因子(transcription factor)是一群能与基因5`端上游特定序列专一性结合，从而保证目的基因以特定的强度在特定的时间与空间表达的蛋白质分子。【转录因子结合特点】转录因子的结合位点（transcription factor binding site，TFBS）是转录因子调节...
Binding of transcription factors to transcription factor binding sites (TFBSs) is key to the mediation of transcriptional regulation. Information on experimentally validated functional TFBSs is limited and consequently there is a need for accurate predic
Transposase-Accessible Chromatin followed by sequencing (ATAC-seq) is a simple protocol for detection of open chromatin. Computational footprinting, the search for regions with depletion of cleavage events due to transcription factor binding, is poorly u
Context-dependent transcription factor (TF) binding is one reason for differences in gene expression patterns between different cellular states. Chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) identifies genome-wide TF bin
Recently, deep learning based models have been proposed and have shown competitive results on a transcription factor binding site prediction task. However, it is difficult to interpret the prediction results obtained from the previous models. In addition, the previous models assumed all the sequence ...
A sequence motif is a short recurring pattern with biological significance such as a DNA-recognition sequence for a transcription factor (TF), an mRNA splicing signal, or a functional region of a protein domain. Many high-throughput experimental approaches and computational tools have been developed...