Organisms determine the transcription rates of thousands of genes through a few modes of regulation that recur across the genome1. In bacteria, the relationship between the regulatory architecture of a gene and its expression is well understood for individual model gene circuits2,3. However, a broa...
AlessandroBisello,Peter A.Friedman, inPrinciples of Bone Biology (Third Edition), 2008 Transcription Factors A major effect of PTH and PTHrP in osteoblasts is directed to modulating the expression and/or function of a number of transcription factors known to be important in bone metabolism. Among...
perturbations, thereby conferring robustness during speciation. This study can facilitate adoption of the pig as a biomedical model for human biology and disease and uncovers the molecular bases of valuable traits. Similar content being viewed by others Pig genome functional annotation enhances the biolog...
AlessandroBisello,Peter A.Friedman, inPrinciples of Bone Biology (Third Edition), 2008 Transcription Factors A major effect ofPTHandPTHrPin osteoblasts is directed to modulating the expression and/or function of a number of transcription factors known to be important inbone metabolism. Among thes...
Long non-protein-coding RNAs (lncRNAs) are proposed to be the largest transcript class in the mouse and human transcriptomes. Two important questions are whether all lncRNAs are functional and how they could exert a function. Several lncRNAs have been sh
(HATs and HDACs) appeared to be highly expressed whereas others showed a low level of expression. As expected, high expression of every histone transcript, corresponding to the most abundant proteins encountered in eukaryote nuclei, (eight annotated in PlasmoDB) was also observed and maximal ...
a Bar plot showing the number of independent index sc-caQTLs reaching genome-level FDR < 0.1 per cell type, colored by the number of cell types where a sc-caQTL is significant. b Bar plot showing the number of sc-caPeaks reaching genome-level FDR < 0.1 per cell type, ...
binding patterns. These and other stochastic events introduce unpredictability into the expression of a specific gene, even when the gene is receiving signals that would be expected to activate its expression. The result is physiological variety at a population level and this can benefit the ...
Finally, we expect our results to be of value in the field of synthetic biology, which aims to engineer genetic networks with desired level of responsiveness to environmental cues by, among other, tuning the sensitivity to fluctuations in cellular component numbers at the single gene level. We ...
Second, we measured the level of proteins in a lysate and calculated the enrichment rank proportional to the difference in the abundance between lysates and a target pulldown. With all the metrics combined, 19 of 20 proteins among the top-most ranking 2% were known RNAP interactors (Fig. 1d...