GNG5 plays an important role in a range of cell processes. It was found that miR-let-7b-5p modulated GNG5 protein levels to affect lung cancer cell proliferation and apoptosis26. Also, GNG5 promoted glioma cell functions, and its expression level was negatively correlated with patient’s over...
Violin plot showing the expression level of REST and NR3C1 across retinal cell types (n = 50,000 cells). Genome track of REST locus showing cell type-specific chromatin accessibility and positioning of rs62308155 within an OCR that is a predicted LCRE of REST. f Violin plot showing ...
3b–d), reducing the OCR to a similar level as β-oxidation-driven respiration (Fig. 3a). To summarize, the bioenergetic characterization of liver mitochondria from IMT-treated mice showed maintained fatty acid oxidation capacity despite markedly reduced OXPHOS capacity. Fig. 3...
Besides its role in mRNA stability, the Csr system is indeed involved in post-translational regulation through the CsrA-dependent activation of enzyme activity18. The CsrA activity is itself regulated via sequestration by the sRNA CsrB, CsrC and McaS19–22. At the transcriptional level, CsrA ...
TUB-deficient cells, like those lacking MYC (Figure S3C), also showed a profoundly reduced level of intracellular NAD+ (Figure 2F). Accordingly, ectopic expression of TUB in Jurkat cells led to a robust increase of both NAMPT (Figures 2C and 2E) and intracellular NAD+ levels (Figure 2F)....
Furthermore, 84.73 % of TFs (111) were expressed in all tissues suggesting a control of a broad set of genes at transcriptional level. The AP2 genesAP2si131,AP2si31andAP2si27exhibited stem-specific expression; the ERF geneAP2si115exhibited root-specific expression while no specific gene ...
Violin plot showing the expression level of SLC27A6 and FOXP2 across retinal cell types (n = 50,000 cells). Genome track of SLC27A6 locus showing cell type-specific chromatin accessibility and positioning of rs10793810 within an OCR that is a predicted LCRE of SLC27A6. e Box plot ...
Methylation of non-CpG sites is a highly controlled process, but how non-CpG methylation controls DNA/protein interactions and regulates transcription is largely unknown15,16. Although the methylation level of DNA is lower in the transcription promoter region than that of the gene body region5, ...
On the other hand, we noticed that NC decreased significantly the level of -sscDNA when amount of NC was exceeded at a certain level (15 pmol per 20 ul of reaction). This threshold of the NC under this condition corresponded to be ~100 molecules per viral RNA. This value ...
In the putative –35 promoter element of P2, the double-base substitution of TT to GG at positions –35 and –34 (mt2) resulted in a drastic reduction of the transcript level to 16% compared with the intact PrrnB_P2 (Fig. 2b), suggesting decreases in activity of the putative P2 ...