Trans-11 vaccenic acid [VA; 18:1(n-9)] is a positional and geometric isomer of oleic acid and is the precursor to conjugated linoleic acid (CLA) in humans. Despite VA being the predominant trans monoene in ruminant-derived lipids, very little is known about its nutritional bioactivity, ...
No association was found between intake of vaccenic acid and breast cancer risk (HR for highest vs lowest quintiles, 1.02, 95% CI 0.95–1.10; P trend = 0.51). For RTFAs, there was little evidence of heterogeneity by hormonal receptor status (Table 3 and Additional file 1: Tables S4...
11,15 A naturally occurring 18-carbon trans fatty acid with a single double bond at position 11 is called octadec-11-enoic acid (IUPAC), C18:1trans11 (lipid number), or vaccenic acid (common name).33 Naturally occurring trans fatty acids are found in predominantly non–grass-fed meat and...
cis-9, trans-11 conjugated linoleic acid is synthesized directly from vaccenic acid in lactating dairy cattle. Conversion of dietary VA to cis-9, trans-11 CLA endogenously was confirmed with the mammary gland being the primary site of Delta9-desaturase activity; ... E Erin,Mosley,Bahman,......
The objective of the present study was to investigate the effects of 2 major trans 18:1 isomers, trans-9 18:1 (elaidic acid (EA)] and trans-11 18:1 [vaccenic acid (VA)] on plasma lipid biomarkers of CHD risk. Thirty-two male Golden Syrian hamsters were randomly assigned to 1 of 4...
We investigated the effects of two common fatty acids - vaccenic acid (VA - found in dairy products), and elaidic acid (EA - found in hydrogenated vegetable oils) on cell death in primary rat ventricular myofibroblasts (rVF). VA- and EA-treated cells exhibited apoptotic cell death in rVF,...
Samples were analyzed using an isotope dilution-gas chromatography-mass spectrometry method validated for the analysis of 28 FA, including the 4 major TFA: palmitelaidic acid, elaidic acid, vaccenic acid, and linoelaidic acid. The TFAs were detected in all samples, with median total TFA ...
The concentrations of trans-11 C18:1 (vaccenic acid; VA) and cis-9 trans-11 CLA were greater (P < 0.01) with the high than the low forage diets and concentrations increased (P < 0.01) with oil supplementation particularly when added with the high forage diet (P < 0.01). The ...
Likewise, profiles of trans-18:1 and CLA isomers were unchanged by antibiotics, but across treatments the predominant trans-18:1 isomer was 10t-18:1 (where t = trans; 3.22%) at 3 times the concentration of the second most abundant isomer (11t-18:1; vaccenic acid, 1.05%). Rumenic ...
In a double-blind randomized-controlled crossover feeding trial healthy adults (N=106; 47M, 59F) were fed 4 diets for 24 days each: 0.1% en mixed isomers TFA (control), 3.0% en highly-purified vaccenic acid (VA), 3.0% en mixed isomers iTFA, and 1.0% en c9,t11-CLA. Total fat (...