Objectives Tramadol is a widely prescribed analgesic that influences both opioid and monoamine neurotransmission. While seizures have been reported with its use, the risk in clinical practice has not been well characterised. We examined risk of seizure with tramadol relative to codeine, a comparable ...
seizures are more likely in those who have taken high doses of tramadol or combined tramadol with other medications. Additionally, other factors that can increase the risk of seizure include, but are not limited to:
This means that you create a strong breakdown product from tramadol more quickly than others, and are at risk for dangerous or even fatal slowed breathing (respiratory depression) or overdose.Learn more: How do genetics affect tramadol?Serious side effects including seizures and serotonin syndrome ...
Seizures have occurred in some people taking tramadol. Your seizure risk may be higher if you have ever had: a head injury, epilepsy, or other seizure disorder drug or alcohol addiction or a metabolic disorder. To make sure tramadol is safe for you, tell your doctor if you have ever had...
Tramadol: Understanding the Risk of Serotonin Syndrome and Seizures Tramadol is commonly prescribed for pain control because it presents a lower risk for addiction and respiratory depression compared to other opioids. Howev... S Hassamal,K Miotto,W Dale,... - 《American Journal of Medicine》 被...
We conducted a study of the risk of idiopathic incident seizures among users of tramadol derived from data present in the General Practice Research Databas... Hershel Jick,Laura E. Derby,Catherine Vasilakis,... - 《Pharmacotherapy the Journal of Human Pharmacology & Drug Therapy》 被引量: 178发...
Ingestion of tramadol as a means of self-harm and age were not associated with an increased risk of seizures. There was no significant association between naloxone administration and seizures (OR = 0.30, 95% CI 0.07–1.25). Conclusions : Based on data from the ToxIC registry, tramadol ...
With fewerside effectspresent, tramadol is recommended for use in elderly persons. Cautious use is recommended in patients concomitantly usingMAO inhibitors,tricyclic antidepressants, orselective serotonin reuptake inhibitorsbecause of an increased risk ofseizures[63]. Spinally and supraspinally, tramadol is...
Tramadol administration was observed to cause the production of seizure-like behavioral syndrome in mice assessed by the frequency of facial movements, head nodding, forelimb clonus, falling and clonic seizures. In addition, the severity caused by tramadol was dose-dependent (Fig.1). ...
Furthermore, patients with epilepsy, a history of seizures, or other risk factors for seizure (head trauma, alcohol or drug withdrawal) also may be at increased risk for developing seizures from tramadol. Drug Interactions The metabolism of tramadol and its active metabolite, M1, is induced with...