Antibiotic resistance genes evolve in the environment, in animals, and in humans; strategic action is needed on all three fronts to help understand resistance and to limit its spread.doi:10.1038/s41591-022-01752
Keywords Enterococcus antibiotic resistance origins speciation terrestrialization commensal early life Paleozoic hospital acquired infection Introduction Enterococci, typically <0.1% of the core gut microbiota of humans (Schloissnig et al., 2013), emerged from that vast diversity to become leading multidrug...
K. et al. Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study. Lancet Infect Dis 10, 597–602 (2010). 42. Bielaszewska, M. et al. Characterisation of the Escherichia coli strain associated with an outbreak ...
The ATP binding cassette (ABC) transporters superfamily is one of the largest classes of membrane proteins. The core of the ABC transporter protein is composed of transmembrane domains (TMDs) and nucleotide binding domains (NBD). Eukaryotes ABC transporters are classified into seven main families (A...
This chapter provides an overview of existing technologies for characterizing Campylobacter isolates, in comparison to the use of pan-genomic microarrays. It is clear that microarray tools allow insight in the genetic factors important for host specificity, virulence, adaptation and antibiotic resistance....
of hAML cells relapsing to chemotherapy. Using this approach, we find that standard chemotherapy drives the selection of a pre-determined set of recurring AML clones with increased in vivo leukemia-initiating capacity and resistance to a second round of chemotherapy. Strikingly, we reveal that low-...