Antibiotic resistance genes evolve in the environment, in animals, and in humans; strategic action is needed on all three fronts to help understand resistance and to limit its spread.doi:10.1038/s41591-022-01752-zChristina M. J. E. Vandenbroucke-Grauls...
Terrestrialization selected for a hardened cell wall leading to antibiotic resistance • Enterococcal speciation: energy source driven, parallels host radiation, or extinction Summary We examined the evolutionary history of leading multidrug resistant hospital pathogens, the enterococci, to their origin hund...
Chemotherapy resistance (chemoresistance) is a major driver of cancer recurrence1. Intra-tumor heterogeneity (ITH), the end product of co-existing microenvironmental, phenotypical, transcriptomic, epigenetic, and genetic variants, drives chemoresistance by providing multiple substrates for tumor escape under...
The ATP binding cassette (ABC) transporters superfamily is one of the largest classes of membrane proteins. The core of the ABC transporter protein is composed of transmembrane domains (TMDs) and nucleotide binding domains (NBD). Eukaryotes ABC transporters are classified into seven main families (A...