Kumar A, Soumerai J, Abramson JS, et al. Zanubrutinib, obinutuzumab, and venetoclax for first-line treatment of mantle cell lymphoma with a TP53 mutation. Blood. 2025 Jan 30;145(5):497-507. doi: 10.1182/blood.2024025563. 编...
[8] Guo Y, Song J, Wang Y, et al. Concurrent Genetic Alterations and Other Biomarkers Predict Treatment Efficacy of EGFR-TKIs in EGFR-Mutant Non-Small Cell Lung Cancer: A Review. Front Oncol. 2020;10:610923. [9] Le X, ...
6、Integrated analysis reveals TP53 mutation as a biomarker of anti-PD-1/PD-L1 treatment for epidermal growth factor receptor (EGFR)-mutant lung adenocarcinoma patients.
[10]Graziano F, Fischer NW, Bagaloni I, et al. TP53 Mutation Analysis in Gastric Cancer and Clinical Outcomes of Patients with Metastatic Disease Treated with Ramucirumab/Paclitaxel or Standard Chemotherapy. Cancers (Basel). 2020;12(8):E2049. Publis...
6、Integrated analysis reveals TP53 mutation as a biomarker of anti-PD-1/PD-L1 treatment for epidermal growth factor receptor (EGFR)-mutant lung adenocarcinoma patients.
[2] Shang K, Huang H, Xu Y, Liu Y, Lu Z, Chen L. Efficacy and safety analyses of epidermal growth factor receptor tyrosine kinase inhibitors combined with chemotherapy in the treatment of advanced non-small-cell lun...
TP53(或p53)被认为是区分高级别浆液性卵巢癌(后简称高浆)与低级别浆液性卵巢癌(后简称低浆)的标记物之一;高浆通常具有TP53突变。 与其他癌种不同,高浆与低浆并不是同一类型肿瘤的两种分化形式,而是两种不同起源的肿瘤;除少数早期误读性报告[2][3]外,低浆不会通过发生TP53突变直接转化为高浆,这些误读性报告...
EGFR和TP53共突变在非小细胞肺癌中的临床意义 转自：医学界 探索TP53突变的分类和意义。靶向治疗的出现显著改善了驱动基因阳性非小细胞肺癌（Non-Small-Cell Lung Cancer，NSCLC）患者的生存预后，基于EGFR、ALK、ROS1、KRAS、BRAF等驱动基因的靶向治疗药物研发和上市，将NSCLC患者的诊疗格局推向了精准诊疗的时代。随着...
Understanding the genetic and nongenetic determinants of tumor protein 53 (TP53)-mutation-driven clonal evolution and subsequent transformation is a crucial step toward the design of rational therapeutic strategies. Here we carry ou...
Fig. 5: RFS correlates with protein structure, mutation frequency and evolutionary conservation. DNA结合的p53 DBD二聚体结构以RFS着色(PDB 3KZ8 (参考文献83))。DBD-DNA和二聚体内的相互作用界面在10 Å距离内显示为球模型,并叠加在卡通模型上,以突出其对突变的敏感性(红色,正RFS值)。