TP53基因检测是指通过检测某个个体的TP53基因（也称为肿瘤基因p53）来评估患者对抗癌发作的风险。它是世...
Cancer-like mutations increased with age in Pap test samples from women without cancer (p<0.01, R2=0.23) but not in patients with HGSOC. Age-adjusted logistic regression confirmed that cancer-likeTP53mutation frequency was associated with HGSOC in patients with germlineBRCAmutations (OR: 4.2, ...
The gene mutation in this individual’s family is known. What other test might be appropriate? Question 3. What are the clinical indications for this testing? Question 4. Whom can I ask for help regarding a specific case? Question 5. When is the right time to pursue this test? Question ...
P53染色百分比作为分类变量,分类变量与数字变量通过卡方检验进行比较,总体生存率(OS)是指从疾病诊断那天至任何原因死亡的时间,用Kaplan-Meier 曲线分析计算存活率,用 log-rank test方法进行存活率的比较,数据采用SPSS22.0处理,统计数据计算P<0.05有意义。
Accordingly, p53 aberrant expression was tightly associated with a TP53 mutation (p < 0.001). In discordant cases, molecular analysis revealed no alteration in three tumors with p53 overexpression. In contrast, in 14 tumors with wild-type p53 expression, TP53 genetic alteration was detected. ...
Due to the frequent occurrence of TP53 as a concomitant mutation, relevant studies have explored the prognosis and drug resistance of TP53 and other genotype co mutations [24,25,26,27]. In this study, Wilcoxon rank sum test analysis showed a correlation between TP53 and nodule growth (P =...
ConclusionGene test are recommended for children and their families with SHH subtype medulloblastoma and choroid plexus cancer to rule out germline TP53 mutation and to provide an individualized treatment plan for patients with LFS...
9 RegisterLog in Sign up with one click: Facebook Twitter Google Share on Facebook TP53 Medical Acronyms Wikipedia (tē′pē′fĭf′tē-thrē′) n. Seep53. [t(umor) p(rotein) 53; seep53.] American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by ...
Brazilian and Spanish heterozygote patients would be necessary to confirm this hypothesis. On the other hand, several of the identified variants, regardless of their germline or somatic origins, were located in knownTP53mutation hotspots, affecting residues 245, 248, 273, and 282, but not hotspots...
We retrieved the RSEM normalised counts for BCAR1 gene along with TP53 mutation status (wild type or mutant), survival months, and status (alive or dead). After filtering off samples with missing information, METABRIC dataset has 1904 samples composed of TP53 mutated (n = 659) and TP53...