Definition The IARC TP53 mutation database is a public web-based resource for the analysis and interpretation of the biological and clinical impacts of TP53 gene variations in human cancers ( http://www-p53.iarc.fr ). It contains data that are compiled from the scientific literature and ...
The IARC TP53 mutation database: a resource for studying the significance of TP53 mutations in human cancerslt;p class=MsoNormalgt;lt;span style=font-size: 10pt; font-family: QuorumITCbyBT-Bookgt;The tumor suppressor gene TP53 is frequently inactivated by gene mutations in many types of ...
1. Mutation distribution 查看以下两种信息的分布 Mutation type Mutation effects Mutation type的结果示意如下 Mutation effects的结果示意如下 2. Tumor distribution 查看somatic mutations和germline mutations在各种肿瘤上的分布,结果以柱状图展现,结果示意如下 如果需要深入研究TP53基因的相关突变,该数据库非常值得参考。
The mutational landscape of TP53, a tumor suppressor mutated in about half of all cancers, includes over 2,000 known missense mutations. To fully leverage TP53 mutation status for personalized medicine, a thorough understanding of the functional diversit
[7] Zenz T, Vollmer D, Trbusek M, et al. TP53 mutation profile in chronic lymphocytic leukemia: evidence for a disease specific profile from a comprehensive analysis of 268 mutations. Leukemia. 2010. 24(12): 2072-9. [8] Varley JM. Ge...
1. Mutation distribution 查看以下两种信息的分布 Mutation type Mutation effects Mutation type的结果示意如下 Mutation effects的结果示意如下 2. Tumor distribution 查看somatic mutations和germline mutations在各种肿瘤上的分布,结果以柱状图展现,结果示意如下
In order to gain a deeper knowledge about the significance of all of these mutants, we have cross-checked each mutant of the TP53 mutation database for its activity, derived from a library of 2,314 TP53 mutants representing all possible amino acid substitutions caused by a point mutation. ...
分析Ⅱ/Ⅲ期结直肠癌患者的临床病理特征,比较不同TP53状态与Ⅱ/Ⅲ期结直肠癌临床病理特征的关系,采用Kaplan-Meier法绘制生存曲线,Log-rank检验进行Ⅱ/Ⅲ期结直肠癌患者的生存分析,采用Cox比例风险回归模型进行Ⅱ/Ⅲ期结直肠癌患者预后...
The IARC TP53 Database (R17Sporadic and hereditary brain tumorsBrain tumor gradesAge at onsetBiological diversity in the development and progression of brain tumors may be based on the consequences of the nature of the TP53 mutation in the cancer sample. This study was designed to estimate the ...
Mutation type 2. Mutation effects Mutation type 的结果示意如下 Mutation effects 的结果示意如下2. Tumor distribution 查看 somatic mutations 和 germline mutations 在各种肿瘤上 的分布,结果以柱状图展现,结果示意如下 如果需要深入研究 TP53 基因的相关突变,该数据库非常值得参考。 ·end·...