Neurotoxins can cause disease by interfering with brain metabolism. The present chapter describes metabolic effects of methionine sulfoximine (MSO), 3-nitropropionic acid (3-NPA), aminooxyacetic acid (AOAA), and methylmercury (MeHg) on astrocytes and neurons in culture. Often toxins act in a cell...
Cell to Cell Signals in Plants and Animals || Phytotoxins and Plant Pathogenesis This book comprises 26 papers and summaries of 40 posters presented at the NATO Advanced Research Workshop on Phytotoxins and plant pathogenesis held at Ca... V Neuhoff,J Friend 被引量: 0发表: 1991年 Phytotoxin...
The pacific oyster Crassostrea gigas was experimentally exposed to the neurotoxic Alexandrium catenella and a non-producer of PSTs, Alexandrium tamarense (control algae), at concentrations corresponding to those observed during the blooming period. At fixed time intervals, from 0 to 48 h, we determin...
Structural modularity enables toxins with the same pore-forming mechanism to target different host cell types by binding to different receptors For PFTs that contribute to infection, examining their structures, dynamics and interactions with host cells at molecular resolution provides cues for the developm...
Patrick J, Jones NF.,: Cell sodium, potassium and water in uraemia and the effects of regular dialysis as studied in the leucocyte.Clin Sei Mol Med46: 583, 1974 CASGoogle Scholar Teschan PE, Post RS, Smith LH, Abernathy RS, Davis JH, Gray DM, Howard JM, Johnson KE, Klopp E, Mundy...
Dendroaspis angusticeps, have high affinity for m1 receptors compared to their affinity at other subtypes of muscarinic acetylcholine receptors, while MTx3 has high affinity for m4 receptors.We have used the toxins to study the muscarinic receptors in the rabbit vas deferens and the guinea pig ute...
random distribution of residues around the specified β-strands in the target toxin (dark purple), successive RFdiffusion denoising steps progressively removed the noise leading at the end of the trajectory to a folded structure interacting with α-cobratoxin β-strands. Schematics ina–cwere created...
the initial year one survey to be highly impacted by microcystin toxin. SPATT was deployed weekly at each site and whole water was collected and analyzed for temperature, ammonium, urea, nitrate, phosphate, silicate, and total toxin, with the whole water samples corresponding to the deployment ...
We observed that Stx1 induces multiple C-X-C chemokines at the mRNA level, including interleukin-8 (IL-8), GRO-alpha, GRO-beta, GRO-gamma, and ENA-78. Like that of IL-8, GRO-alpha and ENA-78 mRNAs are both induced and superinduced by Stx1. Furthermore, Stx1 induces both IL-8...
c Representative HEK293 cell current response to a step depolarisation from –90 to –20 mV in the absence (black) and presence of Ta3a (30 nM, orange). d hNaV1.7 sustained current (current amplitude at 40-ms) evoked by a step depolarisation from –90 to –20 mV before (...