The effect of toxic and non-toxic phenytoin levels on carbohydrate tolerance and insulin levels was studied in 18 patients with epilepsy and 17 control subjects. Toxic levels were defined as a serum level greater than 20 渭g/ml. Toxic levels occurred in 11 patients and non-toxic levels in ...
The main exception is phenytoin, whose metabolism changes from first-order to zero-order kinetics when the enzyme system responsible for its catabolism saturates. Then a small increment in oral dose produces large increments in blood concentration. The half-lives of the antiepileptic drugs listed in...
Cerebellar structures are among the most sensitive targets of the central nervous system (CNS) to ethanol intake. In addition to ethanol, drugs such as phenytoin, antineoplastics, lithium salts, and heroin can cause an irreversible cerebellar syndrome. Environmental causes of TOICS include chronic ...
Teratogenic.Toxicant alters fetal development, resulting inbirth defects(e.g.,phenytoinis associated with development of cleft lip). Target Organs Toxicity may be systemic, affecting the whole body, or it may be largely confined to select target organs, the so-calledtoxic effectorgans. Some organs...
were more likely to have carbamazepine or phenytoin-induced SJS and TEN [11], while those who expressed HLA-B*5801 were more likely to have the reaction after allopurinol exposure [26]. Other MHC allotypes have also been associated with development of SJS and TEN upon exposure of these medic...
A high development of the agonist-antagonist function is essential to the development of dynamic balance. Is the statement true or false? Which of the following drugs is used in the treatment of Parkinsonian disorders? a) Phenytoin b) Selegiline c) Haloperidol d) Fluoxetine What...
UseofMeperidineinPatient-ControlledAnalgesia andtheDevelopmentofaNormeperidine ToxicReaction ThomasT.Simopoulos,MD;HowardS.Smith,MD;ChristinePeeters-Asdourian,MD;DonaldS.Stevens,MD Hypothesis:Intravenouspatient-controlledanalgesia(IV PCA)meperidinehydrochloridecanbeusedwitharea- ...
Such a reaction is called EMPACT (erythemamultiforme associatedwith phenytoin and cranial radiation therapy). The development of TEN after radiation therapy is seldom reported.Owczarczyk-Saczonek, Agnieszka B.Placek, Waldemar J.Rybak-d'Obyrn, Joanna...
Treatment of posttraumatic stress disorder with phenytoin: an open-label pilot study. J Clin Psychiatry 65: 1559–1564. Article Google Scholar Bremner JD, Randall P, Scott TM, Bronen RA, Seibyl JP, Southwick SM et al (1995). MRI-based measurement of hippocampal volume in patients with ...
5 A recent case-control study6 identified that drugs with the highest risk of inducing SJS-TEN included allopurinol, anti-infective sulfonamides (eg, cotrimoxazole), phenytoin, carbamazepine, phenobarbital, lamotrigine (an antiepileptic drug), nevirapine (an anti–human immunodeficiency virus [HIV] ...