National report — Decreasing levels of estrogen in menopause are linked to effects on the skin, such as increased skin laxity, wrinkling and poor wound healing, prompting research targeted at topical administration of estrogens.Louise GagnonAdvanstar...
On This PageTopical Estrogen: Overview Why it is recommended Topical Estrogen can help with the following: Circulation Poor/Slow Wound Healing Complications are more likely to develop in aging skin, such as the progression of a wound to a chronic non-healing state. This is related to an incr...
transdermal- through the unbroken skin; refers to medications applied directly to the skin (creams or ointments) or in time-release forms (skin patches); "transdermal estrogen"; "percutaneous absorption" percutaneous,transcutaneous,transdermic
This study showed a 39% increased risk of recurrence in women using aromatase inhibitors and vaginal estrogen replacement [15]. However, the absence of significant impact on the mortality makes it unclear whether the small (or absent) systemic absorption by vaginal estrogen replacement, as ...
Estrogen replacement therapy by transdermal estradiol administration. Am J Obstet Gynecol. 1983;146:533–540. PubMed CAS Google Scholar Higuchi T. Pharmacy, pharmaceutics and modern drug delivery. Am J Hosp Pharm. 1976;33: 795–800. Google Scholar Blank IH. Transport across the stratum ...
It is thought that the non-skin-irritating formulations may facilitate patient compliance. 展开 关键词: Adis R and D Profiles Estradiol, general Estrogen agonists, general Transdermal 年份: 2003 收藏 引用 批量引用 报错 分享 全部来源 求助全文 国家科技图书文献中心 (权威机构) 掌桥科研 相似文献...
Chromatin immunoprecipitation analysis confirmed that REDD1 is an estrogen receptor (ER) target gene with multiple estrogen response elements in its promoter. Moreover, experiments with GR and ER inhibitors suggested that REDD1 induction by these hormones was interdependent on functional activity of both...
Local skin reactions, all mild, were seen in 4%, and there was a low incidence of side effects that included breast pain, endometrial thickening and headache. Contraindications include those common to all estrogen-containing therapies. This formulation provides patients with a cosmetic-like treatment...
It has been suggested that the potent stimulatory effect of DHEA on bone formation in ovariectomized rats is mainly due to the local formation of androgens in bone cells, because it was inhibited by antiandrogen treatment but not by antiestrogen treatment (Martel et al, 1998). Further ...
A 60-year-old woman was referred for progressive and severe vulvovaginal pain characterized by erosions and Wickham's stria for the past 7 months. Her condition had not responded to oral fluconazole, topical estrogen cream, and topical clobetasol cream. Vulvar and vaginal biopsies were obtained ...