Adverse Effects The major toxicities of tobramycin includenephrotoxicityandototoxicity(vestibular and cochlear). Neuromuscular blockade may also occur.Hypomagnesemia,hypokalemia,hypocalcemia,blood dyscrasias, and delirium have been reported with tobramycin. Although the nephrotoxicity of tobramycin is less than tha...
Developmental and health benefits of breastfeeding should be considered along with mother's clinical need for therapy and any potential adverse effects on breastfed infant from drug or from underlying maternal condition Pregnancy Categories A: Generally acceptable. Controlled studies in pregnant women show...
ADVERSE REACTIONS Neurotoxicity Adverse effects on both the vestibular and auditory branches of the eighth nerve have been noted, especially in patients receiving high doses or prolonged therapy, in those given previous courses of therapy with an ototoxin, and in cases of dehydration. Symptoms ...
To compare ofloxacin solution with a combination of fortified antibiotic cefazolin sodium and tobramycin sulfate solutions in the treatment of bacterial keratitis. Patients under care at any one of 28 participating clinical centers who had an eye with suspected bacterial keratitis were randomly allocated ...
Purpose:To compare ofloxacin solution with a combination of fortified antibiotic cefazolin sodium and tobramycin sulfate solutions in the treatment of bacterial keratitis. Methods:Patients under care at any one of 28 participating clinical centers who had an eye with suspected bacterial keratitis were ran...
Side Effects for Tobradex The most frequent adverse reactions to TOBREX (tobramycin ophthalmic solution) 0.3% are hypersensitivity and localized ocular toxicity, including lid itching and swelling, and conjunctival erythema. These reactions occur in less than three of 100 patients treated with TOBREX®...
loteprednol etabonate or tobramycin in human milk, effects on breastfed infants, or on milk production; the developmental and health benefits of breastfeeding should be considered, along with the mother’s clinical need for therapy and any potential adverse effects on the breastfed infant from the...
Side Effects for Tobradex ST Clinical Trials Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates ob...
effects of the drugs. Larger droplets deposited in the upper respiratory tract are indeed rapidly cleared from the lung by the mucociliary clearance process, with the effect that drug becomes available for systemic absorption and potentially adverse effects. The same problems could occur with too ...
11. The solution of claim 10 wherein the tonicity compound is selected from the group consisting of sodium chloride, sodium sulfate, glycerol, mannitol and sorbitol. 12. The solution of claim 9 wherein a tonicity compound is added to the solution. ...