TOBI should be used cautiously in patients with neuromuscular disorders, such as myasthenia gravis or Parkinson's disease, since aminoglycosides may aggravate muscle weakness because of a potential curare-like effect on neuromuscular function. Bronchospasm ...
368 EVALUATION OF POTENTIAL NEPHROTOXICITY OF AMIKACIN AND TOBRAMYCIN IN PREMATURE INFANTSThe nephrotoxicity(NT) of aminoglycosides in premature infants is a still disputed problem. To assess and compare this possible side-effect of two widely used compounds, tobramycin (TB) and amikacin (AK) we ...
Aminoglycosides, including tobramycin, may aggravate muscle weakness because of a potential curare-like effect on neuromuscular function. Neuromuscular blockade, respiratory failure, and prolonged respiratory paralysis may occur more commonly in patients with underlying neuromuscular disorders, such as myasthenia...
improving lung function and sputumP. aeruginosadensity in these patients without the nephrotoxicity or ototoxicity of parenteral aminoglycosides. Further data on the potential for and clinical significance of increased tobramycin resistance and
▪ Drug Interactions Use with other drugs having neurotoxic or ototoxic potential should be avoided. Some diuretics enhance aminoglycoside toxicity by altering antibiotic concentrations in serum and tissue. Should not be used with ethacrynic acid, furosemide, mannitol, or urea. ▪ References Ferrin...
Aminoglycosides may aggravate muscle weakness in patients with known or suspected neuromuscular disorders, such as myasthenia gravis or Parkinson’s disease, because of their potential effect on neuromuscular function. Drug Interactions for Tobrex No Information Provided Warnings for Tobrex NOT FOR INJECTION...
妥布霉素地塞米松滴眼液(TobramycinDexamethasoneEyeDrops)妥布霉素地塞米松滴眼液(tobramycindexamethasoneeyedrops)(典必殊)本品为复方制剂,其组分为:..
Understanding bacterial biofilms in patients with cystic fibrosis: current and innovative approaches to potential therapies. J Cyst Fibros. 2002;1(4):249–254. 21. Smith AL, Ramsey BW, Hedges DL, et al. Safety of aerosol tobramycin administration for 3 months to patients with cystic fibrosis. ...
This is of potential relevance, as the capillaries of the stria vascularis are flanked by melanocytes, which excrete melanin and control vascular permeability. These capillaries are the critical point at which blood to endolymph drug transport occurs. Melanocyte expression of pigment epithelial-derived ...
Balakrishnan A, Polli JE (2006) Apical sodium dependent bile acid transporter (ASBT, SLC10A2): a potential prodrug target. Mol Pharm 3(3):223–230 Article CAS PubMed PubMed Central Google Scholar Balakrishnan A, Wring SA, Polli JE (2006) Interaction of native bile acids with human apical...