OX40 is expressed on activated T cells, and in the mouse at rest on regulatory T cells (Treg). CD134 can interact with TRAF2, TRAF3, and TRAF5. OX40 is an immune checkpoint in cancer and its presence in cancer is a good prognosis, making it a highly relevant target for the ...
值得注意的是目前仍缺乏有效的生物标志物来辅助预测喉鳞癌患者的预后.TNFRSF4,肿瘤坏死因子受体超家族成员4,属于活化的T淋巴细胞上的共刺激免疫检查点分子.TNFRSF4在免疫应答中发挥重要作用,它能够使Treg细胞失活,并促进CD8+T细胞的增殖与分化.另有研究表明,TNFRSF4与数种恶性肿瘤的预后有密切相关.此外,众所周知...
Moreover, miR-744 agomir administration significantly enhanced the expression levels of CD62L and Ki67 in CD4+CD25+ Treg cells from heart transplantation mice and further enhanced immunosuppressive function of Treg cells following coculture with CD4+CD25- T cells for different ratios. In addition, ...
Definition Deficiency of tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), previously called OX40, is associated to the development of childhood Kaposi sarcoma. Introduction The human OX-40 receptor (OX40R) cell surface antigen is a CD4+ T cell costimulatory receptor. The gene for...
(12). 4-1BB can associate with OX40 on activated T cells, forming a complex that responds to either ligand and inhibits Treg and CD8+T cell proliferation (13). Reverse signaling through 4-1BB Ligand inhibits the development of dendritic cells, B cells, and osteoclasts (8, 11) but ...
Infusion of anti-TNFRSF25 mAbs further augmented graft survival and increased graft-infiltrating Treg cells. These mAbs also expanded murine and human Treg... Reginald,M.,Gorczynski,... - 《Immunology》 被引量: 2发表: 2017年 ANTI-TNFRSF25 ANTIBODIES in particular to an antibody for a member...
(11). 4‑1BB can associate with OX40 on activated T cells, forming a complex that responds to either ligand and inhibits Treg and CD8+T cell proliferation (12). Reverse signaling through 4‑1BB Ligand inhibits the development of dendritic cells, B cells, and osteoclasts (6, 9) but ...
Yet, the influence of TNFRSF9 on Treg cells is controversial and TNFRSF9 has also been shown to maintain the suppressive capacity of Tregs [21,22]. As well as its expression on activated immune cells, TNFRSF9 is also expressed by inflamed or hypoxic endothelial cells [23] and has been ...
forming a complex that responds to either ligand and inhibits Treg and CD8+ T cell proliferation. Reverse signaling through 4-1BB Ligand inhibits the development of dendritic cells, B cells, and osteoclasts but supports mature dendritic cell survival and costimulates the proliferation and act...