well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul ...
21.Zhang Q, Yu FX, Wu YL, Yang CY, Liu NC, Zhu X, et al. Novel gene therapy for rheumatoid arthritis with single local injection: adeno-associated virus-mediated delivery of A20/TNFAIP3. Mil Med Res. 2022;9(1):34.
The gene TNFAIP3 acts as a negative regulator of the NF-κB signaling pathway. TNFAIP3 encodes the A20 protein,which exerts a potent anti-inflammatory effect and plays a pivotal role in the regulation of inflammation and immunity. In recent years,TNFAIP3 has garnered significant attention as a...
This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The enc...
Gene ID: 7128 种属 Homo sapiens DNA序列编号: NM_001270508.2 DNA描述 Homo sapiens TNF alpha induced protein 3 (TNFAIP3), transcript variant 1, mRNA DNA大小: 4665 bp DNA编码区: atggctgaacaagtccttcctcaggctttgtatttgagcaatatgcggaaagctgtgaag atacgggagagaactccagaagacatttttaaacctactaatgggatcattcatca...
(TNF). The protein encoded by this gene is a zinc finger protein, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. Knockout studies of a similar gene in mice suggested that this gene is critical for limiting inflammation by terminating TNF-induced NF-...
Gene Symbol TNFAIP3 Gene ID (NCBI) 7128 RRID AB_2879284 Conjugate Unconjugated Form Liquid Purification Method Antigen affinity purification UNIPROT ID P21580 Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Storage Conditions Store at -20°C. Stable for one year after shipm...
Conclusions Our data confirm the association of the non-synonymous polymorphism rs2230926 in exon 3 of the TNFAIP3 gene, resulting in an amino acid substitution Phe/Cys, with the risk for RA, particularly for ACPA negative disease. The association of the intronic SNP rs583522 with the risk ...
(TNF). The protein encoded by this gene is a zinc finger protein, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. Knockout studies of a similar gene in mice suggested that this gene is critical for limiting inflammation by terminating TNF-induced NF-...
Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2012] [中文简述(自动翻译):] 该基因被鉴定为其表达迅速被肿瘤坏死因子(TNF)诱导的基因。由该基因编码的蛋白质是一个锌指蛋白和ubiqitin编辑酶,并已被证明对抑制NF-κB的活化以及TNF介导的细胞...