Methods: TNF-Tg mice with advanced arthritis and collapsed popliteal lymph nodes (PLN) were treated with anti-TNF monoclonal antibody (10 mg/kg weekly) or placebo for 6-weeks, and effects on knee synovitis, efferent lymphatic vessel ultrastructure and function, and PLN cellularity were assessed ...
Study on the Efficacy of Zang Bi Formula in Treatment Rheumatoid Arthritis and its Cardiac Hypertrophy Complications in TNF-Tg Mice Based on Network Pharmacology 在线阅读 下载PDF 引用 收藏 分享 摘要 目的通过动物实验观察脏痹方(ZBF)在类风湿关节炎(RA)心脏并发症中的疗效。采用超高效液相色谱串联飞行...
2011. CD23(+)/CD21(hi) B-cell translocation and ipsilateral lymph node collapse is associated with asymmetric arthritic flare in TNF-Tg mice. Arthritis Res. Ther. 13: R138.Li J, Zhou Q, Wood RW, Kuzin I, Bottaro A, Ritchlin CT, Xing L, Schwarz EM. CD23(+)/CD21(hi) B-cell...
TNF-Tg mice (3647 line)39,40,41were initially acquired from Dr. George Kollias and have since been maintained at the University of Rochester. The TNF-Tg mice were bred as heterozygotes, and WT littermates were used as controls (C57BL/6 genetic background). Only male mice were used expe...
Interestingly, the TNF tg mice treated with radon showed an increased survival compared to mock treated TNF tg control mice. Conclusions Radon therapy ameliorates the inflammatory processes responsible for the arthritogenic activity of human TNF in mice. The overall radon dose applied to the mice ...
Lymphatic dysfunction exists in tumor necrosis factor transgenic (TNF-Tg) mice and rheumatoid arthritis (RA) patients. While joint-draining TNF-Tg popliteal lymphatic vessels (PLVs) have deficits in contractility during end-stage arthritis, the nature of
Muscle tissue sections were also stained for macrophages, neutrophils, T cells and B cells.ResultsWe could demonstrate that hTNFtg mice significantly lost muscle weight when compared to sex- and age matched wt animals. Reductions in muscle weight became already manifest at early stages of the ...
In mice, production of mature Paneth ce... CS Weeks,H Tanabe,JE Cummings,... - 《Journal of Biological Chemistry》 被引量: 81发表: 2006年 Chemokines Key Regulators of Mononuclear Cell Recruitment in Atherosclerotic Vascular Disease Understanding the increasingly complex role of chemokines in ...
Topical isoflavonoids reduce experimental cutaneous inflammation in mice The antioxidant and anti-proliferative biological effects of isoflavonoids are relevant properties to counteract the characteristics of many cutaneous dise... M Bandara,SJ Arun,M Allanson,... - 《Immunology & Cell Biology》 被引量:...
Understanding bone marrow edema in arthritis: 3D-MRI & histology analyses of TNF-Tg Mice. Arthritis Rheum 2006;54(Suppl):S798-9.Proulx S, Kwok E, Shealy DJ, Ritchlin CT, Schwarz EM: Under- standing bone marrow edema in arthritis: 3D-MRI and histol- ogy analyses of TNF-Tg mice. ...