TNF-Tg and WT littermates of both sexes underwent mu CT imaging and PFT testing at 5.5 months-old. Spearman's correlation analyses were performed comparing lung tissue volume (LTV) to PFT parameters of gas exchange and tissue stiffness. Results: Compared to WT, TNF-Tg mice had impaired gas...
Confirmation of effective anti-TNF therapy with amelioration of inflammatory-erosive arthritis in TNF-Tg mice. The study design is provided to describe the treatment period along with PLN, PLV, and joint measurements to evaluate anti-TNF therapy efficacy(A). PLN volumes quantified by ultrasound were...
Study on the Efficacy of Zang Bi Formula in Treatment Rheumatoid Arthritis and its Cardiac Hypertrophy Complications in TNF-Tg Mice Based on Network Pharmacology 在线阅读 下载PDF 引用 收藏 分享 摘要 目的通过动物实验观察脏痹方(ZBF)在类风湿关节炎(RA)心脏并发症中的疗效。采用超高效液相色谱串联飞行...
IL-1也许正是这些候选者之一,因为它在关节炎动物模型中也起重要作用,抑制IL-1也成功治疗人类RA。 为了去除TNF介导炎性关节病中IL-1的作用,我们将IL-1alpha和IL-1beta均缺陷小鼠(IL-1-/-)与人TNF转基因小鼠(hTNFtg)杂交。 基 于对IL-1缺陷单核细胞的一种固有分化障碍的检测,与hTNFtg小鼠相比,IL-1-/-...
Muscle tissue sections were also stained for macrophages, neutrophils, T cells and B cells.ResultsWe could demonstrate that hTNFtg mice significantly lost muscle weight when compared to sex- and age matched wt animals. Reductions in muscle weight became already manifest at early stages of the ...
Sorted live Pdpn+ CD45− CD31− Ter119− synovial cells of the ankle joints of WT mice at the age of 4 weeks (n = 3) and hTNFtg mice at 2 different stages of the disease, early at 4 weeks (n = 3) and established at 8 weeks old mice (n = 3), were subjected to 10X ...
Lymphatic dysfunction exists in tumor necrosis factor transgenic (TNF-Tg) mice and rheumatoid arthritis (RA) patients. While joint-draining TNF-Tg popliteal lymphatic vessels (PLVs) have deficits in contractility during end-stage arthritis, the nature of
Small Heterodimer Partner Deficiency Increases Inflammatory Liver Injury Through C-X-C motif chemokine ligand 2-Driven Neutrophil Recruitment in Mice. Authors:Noh JR, Kim YH, Kim DK, Hwang JH, Kim KS, Choi DH, Lee SJ, Lee HG, Lee TG, Weng HL, Dooley S, Choi HS, Lee CH ...
To avoid any sex bias effect in the analyses, mice of both genders were included to generate samples. Sorted live Pdpn+CD45−CD31−Ter119−synovial cells of the ankle joints of WT mice at the age of 4 weeks (n= 3) andhTNFtgmice at 2 different stages of the disease, early at ...
Blocking TNF-α in hTNFtg mice lead to similar biomechanical and histomorphometrical properties as in wild type. Conclusions High levels of TNF-α during chronic inflammation have a negative impact on fracture healing. Our data suggest that TNF-α inhibition by an anti-TNF antibody does not ...