Tumor necrosis factor (TNF ) is a potent pro-inflammatory cytokine that plays an important role in immunity and inflammation, in the control of cell proliferation, differentiation and apoptosis. This paper presents a simulation study of the TNF mediated NF- B signaling pathway based on a system-...
Objective To investigate the role of nuclear factor kappa-B(NF-κB)signaling pathway in tumor necrosis factor α(TNF-α)-induced apoptosis in gastric cancer cells.Methods Human gastric cancer cell line SGC7901 was treated with TNF-α for 24 hours.MTT assay,flowcytometry and Western blot was us...
目的 探索核因子-κB(NF-κB)对肿瘤坏死因子-α(TNF-α)诱导下软骨细胞中基质金属蛋白酶家族(MMPs)与基质金属蛋白酶组织抑制剂家族(TIMPs)比值的影响。方法 采用胰酶消化法从1日龄小鼠的膝关节处提取软骨细胞。HE染色以显示软骨细胞形态;半定量PCR用于分析TNF-α诱导下bay11-7082对软骨细胞中 MMPs和TIMPs 基因表...
目的:通过观察肿瘤坏死因子(TNF-α)以及核转录因子κB(NF-κB)在颅脑损伤后脑组织中的表达变化,初步探讨两者在颅脑损伤后继发性脑损伤中的意义。方法:健康成年雄性SD大鼠64只,体重230-310g,随机分成对照组8只和颅脑损伤组56只,颅脑损伤组在外伤后1h、3h、6h、12h、24h、3d、7d处死,每组处死8只。取损伤灶周围的...
Silymarin blocked TNF-induced activation of NF-kappa B in a dose- and time-dependent manner. This effect was mediated through inhibition of phosphorylation and degradation of Iota kappa B alpha, an inhibitor of NF-kappa B. Silymarin blocked the translocation of p65 to the nucleus without ...
Telmisartan Inhibits TNF alpha-Induced Leukocyte Adhesion by Blocking ICAM-1 Expression in Astroglial Cells but Not in Endothelial Cells adhesion to astrocytes, and that this response was mediated by the inhibition of JNK/ERK1/2/NF-kappa B activation and in the PPAR-independent manner. ... C ...
The aim of this study was to evaluate the effects of grape juice on induced by azoxymethane (AOM) and expression of NF-kB, and -α.Forty male were divided into 7 groups: G1, control; G2, 15 mg/kg AOM; G3, 1% grape juice 2 weeks before AOM; G4, 2% grape juice 2 weeks before...
Silymarin suppresses TNF-induced activation of NF-kappa B, c-Jun N-terminal kinase, and apoptosis SK, Mukhopadhyay A, Van NT, Aggarwal BB (1999) Silymarin suppresses TNF-induced activation of NFkappa B, c-Jun N-terminal kinase, and apoptosis. J... SK Manna,A Mukhopadhyay,NT Van,... -...
Peg3/Pw1 is an imprinted gene involved in the TNF-NF|[kappa]|B signal transduction pathway 来自 Semantic Scholar 喜欢 0 阅读量: 57 作者:F Relaix,XJ Wei,X Wu,DA Sassoon 摘要: Tumor necrosis factor (TNF) mediates a variety of biological activities including cell proliferation, differentiation...
Vitamin C suppresses TNF-α-induced NF-κB activation by inhibiting I kappa B alpha phosphorylation. Biochemistry. 2002; 43 :12995–13002. doi: 10.1021/bi0263210. [ Cross Ref ]Carcamo, J.M.; Pedraza, A.; Borquez-Ojeda, O.;... JM Cárcamo,A Pedraza,O Bórquez-Ojeda,... - 《Bioche...