Signaling pathway via TNF-α/NF-κB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis Nakamura T, et al .: Signaling pathway via TNF-{alpha}/NF-{kappa}B in intestinal epithelial cells may be directly involved in colitis-associated carcino......
Tumor necrosis factor (TNF ) is a potent pro-inflammatory cytokine that plays an important role in immunity and inflammation, in the control of cell proliferation, differentiation and apoptosis. This paper presents a simulation study of the TNF mediated NF- B signaling pathway based on a system-...
目的:通过观察肿瘤坏死因子(TNF-α)以及核转录因子κB(NF-κB)在颅脑损伤后脑组织中的表达变化,初步探讨两者在颅脑损伤后继发性脑损伤中的意义。方法:健康成年雄性SD大鼠64只,体重230-310g,随机分成对照组8只和颅脑损伤组56只,颅脑损伤组在外伤后1h、3h、6h、12h、24h、3d、7d处死,每组处死8只。取损伤灶周围的...
NF-kappa B p65和TNF-α的表达.结果 90%极限门静脉分支结扎后,结扎侧肝叶呈进行性萎缩变小,保留侧肝叶占总肝质量的比例逐渐增加;门静脉压力在结扎后立即升高,0.5 d达到高峰,随后逐渐下降,7 d降至正常水平;PCNA阳性细胞计数在术后第0.5 d至7 d与对照组相比增多(P<0.01),以后逐渐恢复正常.保留侧肝叶的NF-...
However, NF-kappa B activation by TRADD is not inhibited by crmA expression, demonstrating that the signaling pathways for TNF-induced cell death and NF-kappa B activation are distinct. 展开 关键词: Animals Mice 3T3 Cells Tumor Necrosis Factor Receptor-Associated Peptides and Proteins TNF Receptor...
Telmisartan Inhibits TNF alpha-Induced Leukocyte Adhesion by Blocking ICAM-1 Expression in Astroglial Cells but Not in Endothelial Cells adhesion to astrocytes, and that this response was mediated by the inhibition of JNK/ERK1/2/NF-kappa B activation and in the PPAR-independent manner. ... C ...
The aim of this study was to evaluate the effects of grape juice on induced by azoxymethane (AOM) and expression of NF-kB, and -α.Forty male were divided into 7 groups: G1, control; G2, 15 mg/kg AOM; G3, 1% grape juice 2 weeks before AOM; G4, 2% grape juice 2 weeks before...
A novel NF-kappa B/Rel site in intron 1 cooperates with proximal promoter elements to mediate TNF-alpha-induced transcription of the human polymeric Ig rec... Secretory Abs constitute the first line of specific immune defense at mucosal surfaces. Such Abs are generated by the active transport ...
Soluble and transmembrane TNF-like weak inducer of apoptosis differentially activate the classical and noncanonical NF-kappa B pathway. 来自 掌桥科研 喜欢 0 阅读量: 38 作者: C Roos,A Wicovsky,N Muller,S Salzmann,T Rosenthal,H Kalthoff,A Trauzold,A Seher,F Henkler,C Kneitz 展开 摘要: ...
IL-13 Suppresses TNF-Induced Activation of Nuclear Factor-κB, Activation Protein-1, and Apoptosis The activation of N-terminal c-Jun kinase and mitogen-activated protein kinase kinase, implicated in the regulation of AP-1 and NF-kappa B, was also ... SK Manna,BB Aggarwal - 《Journal of ...