NF-kappa BTumor Necrosis Factor自身分泌性细胞交流肺肥大细胞NF-κB肿瘤坏死因子The generation of cytokines, particularly TNF-alpha, by mast cells is crucial for the initiation of the allergic response. A key transcription factor involved in the synthesis of TNF-alpha is NF-kappaB. Using a mAb ...
Trolox also mitigated TNF-α induced changes. Pre-exposure of cells to IKK inhibitor, prevented TNF-α induced changes and inhibition of ERK 1/2 MAP kinase attenuated protective role of IL-10. The study shows that IL-10 prevents TNF-α-induced NFκB activation and proapoptotic changes in ...
Signaling pathway via TNF-α/NF-κB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis Nakamura T, et al .: Signaling pathway via TNF-{alpha}/NF-{kappa}B in intestinal epithelial cells may be directly involved in colitis-associated carcino......
目的:通过观察肿瘤坏死因子(TNF-α)以及核转录因子κB(NF-κB)在颅脑损伤后脑组织中的表达变化,初步探讨两者在颅脑损伤后继发性脑损伤中的意义。方法:健康成年雄性SD大鼠64只,体重230-310g,随机分成对照组8只和颅脑损伤组56只,颅脑损伤组在外伤后1h、3h、6h、12h、24h、3d、7d处死,每组处死8只。取损伤灶周围的...
diallyl disulfide, tumor necrosis factor alpha, monocyte chemoattractant protein 1, nuclear factor kappa b, map kinase bTNFα receptors are constitutively overexpressed in tumor cells, correlating to sustain elevated NFκB and monocyte chemotactic protein-1 (MCP-1/CCL2) expression. The elevation of ...
Tumor necrosis factor (TNF ) is a potent pro-inflammatory cytokine that plays an important role in immunity and inflammation, in the control of cell proliferation, differentiation and apoptosis. This paper presents a simulation study of the TNF mediated NF- B signaling pathway based on a system-...
Activation of cytokine expression occurs through the TNF alpha /NF- kappa B-mediated pathway in birnavirus-infected cellsActivation of cytokine expression occurs through the TNF alpha /NF- kappa B-mediated pathway in birnavirus-infected cellsWangW...
Telmisartan Inhibits TNF alpha-Induced Leukocyte Adhesion by Blocking ICAM-1 Expression in Astroglial Cells but Not in Endothelial Cells adhesion to astrocytes, and that this response was mediated by the inhibition of JNK/ERK1/2/NF-kappa B activation and in the PPAR-independent manner. ... C ...
An RNAi screen identifies USP2 as a factor required for TNF-alpha-induced NF-kappaB signaling. Int J Cancer. 2011; 129:607-618. [PubMed: 21480224]Metzig M, et al. 2011. An RNAi screen identifies USP2 as a factor required for TNF-alpha-induced NF-kappaB signaling. Int. J...
A novel NF-kappa B/Rel site in intron 1 cooperates with proximal promoter elements to mediate TNF-alpha-induced transcription of the human polymeric Ig rec... Secretory Abs constitute the first line of specific immune defense at mucosal surfaces. Such Abs are generated by the active transport ...