For investigating the role of Fc fucosylation in the response to Infliximab we built a 3D mAb model that included the FAB portions of Infliximab complexed with TNFalpha(coordinates from 4G3Y.pdb), the Fc region of IGHG1 fucosylated(3SGJ) and afucosylated(3SGK) with FcγRIIIa. A few ...
Protein and Ligand Preparation: Crystallographic structures of AChE (PDB ID: 7XN1), DA (PDB ID: 6CM4), GABA (PDB ID: 6CDU), and MAO-B (PDB ID: 2V5Z) were obtained from the RCSB Protein Data Bank. The proteins underwent structural optimization and minimization using CHIMERA v1.16, ...