C57BL/6 mice were provided by the breeding unit of the animal facility of Department of Microbiology, Tumor and Cell Biology, Kar- olinska Institute, Sweden; B6.129S2-Tnfrsf1btm1Mwm/J (Tnfr1 À / À ) mice in C57BL/ 6 background were purchased from the Jackson Laboratory (Bar ...
Representative histograms of ICAM-1 expression with MFI values including fluorescence-minus-one (FMO) control (red) are shown. (E) CD33+CD45lowCD3−CD34+ (CD34+) and CD33+CD45lowCD3−CD34− (CD34−) primary AML blasts from 2 patients were treated with rTNFα. The ICAM-1 MFI ...
(n = 1 independent experiments).fAggregation of hTNF +hTNFR1 at a fixed ratio of TNF:TNFR = 1:3.2 over a range of total protein concentrations with UCB-9260 (5-fold excess over TNF) (blue trace) (n = 1 independent experiments, a similar rightward shift in the point ...