Initially, an analysis was done with a fixed ratio of TNF to the receptor (5-fold excess hTNFR1 over hTNF trimer) plus and minus compound UCB-0595 (10-fold molar excess over hTNF trimer). In the sample without compound, as expected, the only form observed was TNF with three receptors...
In addition, silencing of the APRIL receptor (TNFRSF13B) in the TNBC cell line induced significant cell death, indicating the APRIL system as a potential therapeutic target for the TNBC [48]. APRIL serum level was higher in patients with brain tumors in comparison to healthy individuals [49]...