Thus, our data support the concept that both protein synthesis-independent and protein synthesis-dependent forms of synaptic plasticity were altered by chronic neuroinflammation. In addition to its well-known role in inflammation [17], TNF-α has direct effects on glutamate transmission and, notably,...
基因别名 : DIF, TNF, TNF-alpha, TNFA, TNFSF2, TNLG1F 基因ID : (Human) 7124 基因符号 : TNF 蛋白别名 : APC1 protein, Cachectin, DADB-70P7.1, TNF alpha, TNF superfamily, TNF α, TNFα, TNF, macrophage-derived, monocyte-derived, TNF-a, TNF-alpha, Tumor necrosis factor, tumor ...
Recombinant Human TNF-alpha / TNFA Protein, HPLC-verified (Cat. No. 10602-HNAE) was more than 95% and the molecular weight of this protein is around 50.3 kDa verified by SEC-MALS (Routinely tested). Recombinant Human TNF-alpha Protein, HPLC-verified: 别称 ...
High protein concentration, a pH of between about 4 and about 8, and enhanced stability; tumor necrosis factor alpha (tnf-alpha)doi:US20040033228 A1A liquid aqueous pharmaceutical formulation is described which has a high protein concentration, a pH of between about 4 and about 8, and enhanced...
Control of synaptic strength by glial TNFalpha Science, 295 (2002), pp. 2282-2285 View in ScopusGoogle Scholar Belarbi et al., 2012 K. Belarbi, T. Jopson, D. Tweedie, C. Arellano, W. Luo, N.H. Greig, S. Rosi TNF-α protein synthesis inhibitor restores neuronal function and reverses...
TNF-RI signaling is initiated when trimeric TNF-alpha binds TNF-RI receptors. Subsequent TNF-RI trimerization promotes the recruitment of a proximal signaling complex composed of TNF Receptor Associated protein with a Death Domain (TRADD), Receptor Interacting Protein (RIP), cellular Inhibitor of ...
6c). These results indicate that TGFβ priming decreases the protein stability of IRF8 and promotes its degradation, which is also true when protein synthesis is blocked (Fig. 6d). In line with this, the ubiquitination of IRF8 was significantly increased in TGFβ priming conditions when ...
Thalidomide-based TNF-alpha inhibitors for neurodegenerative diseases. Acta Neurobiol Exp. 2004;64:1–9. Google Scholar Belarbi K, Jopson T, Tweedie D, Arellano C, Luo W, Greig NH, Rosi S. TNF-alpha protein synthesis inhibitor restores neuronal function and reverses cognitive deficits induced ...
Parkinson’s disease: A vicious cycle of inflammation and protein aggregation A signaling protein known as a cytokine produced during inflammation promotes the spread of protein aggregates that cause Parkinson’s disease. Several studies have suggested a role for inflammation in forming aggregates of ...
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