此外,由 LTA基因编码的同样隶属于TNSF超家族的TNF-β蛋白,也称为淋巴毒素α(Lymphotoxin Alpha,LT-α),也能与TNFR1和TNFR2相结合。 图2. TNFR1与TNFR2介导的信号通路[3] 小结 作为一种细胞因子,TNF-α在免疫反应中发挥了重要作用,包括促进炎症反应、细胞增殖和分化、细胞凋亡和坏死等。此外,TNF-α的过表达...
TNF-alpha gene polymorphism (-308G/A) and toxoplasmic retinochoroiditis. Br J Ophthal- mol. 2008;92(7):986-8.Cordeiro CA, Moreira PR, Costa GC, Dutra WO, Campos WR, Oréfice F, Teixeira AL 2008b. TNF-alpha gene polymorphism (-308G/A) and toxoplasmic retinochoroiditis. Br J ...
肿瘤坏死因子 -α(Tumor Necrosis Factor-alpha,TNF-α)作为免疫反应中的重要促炎细胞因子,由 TNF-α 基因编码,在宿主抵御结核分枝杆菌感染的过程中发挥着不可或缺的作用。它能够促进肉芽肿的形成和维持,从而有效遏制细菌的扩散,同时还能调节巨噬细胞和 T 细胞等免疫细胞的活性。然而,TNF-α 细胞因子的表达异常,...
目前秋水仙碱、NSAIDs和糖皮质激素等一线用药在急性痛风性关节炎治疗方面发挥着重要作用,但仍有部分患者不能达到预期治疗效果。痛风急性发作过程中有多种炎性细胞、炎性因子参与,其中IL-1在炎症激活和维持中发挥了核心作用。除此之外TNF-α...
[3]. El-Tahan RR, et al. TNF-α gene polymorphisms and expression. Springerplus. 2016 Sep 7;5(1):1508. [4]. Jang DI, et al. The Role of Tumor Necrosis Factor Alpha (TNF-α) in Autoimmune Disease and Current TNF-α Inhibitors in Therapeutics. Int J Mol Sci. 2021 Mar 8;22(5...
Rabbit Anti-TNF alpha Polyclonal Antibody DATASHEET Host:Rabbit Target Protein:TNF alpha IR:Immunogen Range:86-150/233 Clonality:Polyclonal Isotype:IgG Entrez Gene:7124 Swiss Prot:P01375 Source:KLH conjugated synthetic peptide derived from human TNF alpha:86-150/233 ...
XIE H, YAO H, HUO Y, et al. Association between TNF-α gene 308G>A polymorphism and lung cancer risk: a metaanalysis[J]. Tumour Biol, 2014, 35(10): 9693-9699. FLEGO V, RISTIĆ S, DEVIĆ PAVLIĆ S, ...
TNF-alpha gene polymorphism does not affect the clinical and radiological outcome of rheumatoid arthritis. Rheumatol Int. 2000; 19(4): 137-40... JK Lacki,R Moser,I Korczowska,... - 《Rheumatology International》 被引量: 0发表: 2000年 A genetic association study of the IGF-1 gene and...
[3]. El-Tahan RR, et al. TNF-α gene polymorphisms and expression. Springerplus. 2016 Sep 7;5(1):1508. [4]. Jang DI, et al. The Role of Tumor Necrosis Factor Alpha (TNF-α) in Autoimmune Disease and Current TNF-α Inhibitors in Therapeutics. Int J Mol Sci. 2021 Mar 8;22(5...
TNFalpha gene polymorphisms in the pathogenesis of acne vulgaris. Inflammation plays an important role in acne pathogenesis, and pro-inflammatory cytokines are key factors in these events. Tumor necrosis factor alpha (TNF... K Szabo,G Tax,BD Teodorescu,... - 《Archives of Dermatological Research...