应该是NF-kappa B吧。没记错的话是一个转录因子。nuclear factor kappa B (NF-κB)。由于最初发现此因子能启动 B淋巴细胞中免疫球蛋白kappa轻链 基因的转录而命名。读法就是字面读法。TNF-alpha，肿瘤坏死因子alpha。读法也是一个一个字母字面上得读法。
The Effects of NF-kappa B Signalling on the TNF-alpha-induced Ratios of MMPs to TIMPs in Chondrocytes 中文关键词:软骨细胞 肿瘤坏死因子-α 核因子-κB 基质金属蛋白酶家族 基质金属蛋白酶组织抑制剂家族 英文关键词:Chondrocyte TNF-α NF-κB MMPs TIMPs ...
TNF-alpha modulates angiopoietin-1 expression in rheumatoid synovial fibroblasts via the NF-kappa B signalling pathway. Angiopoietin-1 (Ang-1) is one of a family of ligands for the Tie-2 receptor which has been demonstrated to be involved in angiogenesis. Little is known abo... BB Scott,PF...
目的:通过观察肿瘤坏死因子(TNF-α)以及核转录因子κB(NF-κB)在颅脑损伤后脑组织中的表达变化,初步探讨两者在颅脑损伤后继发性脑损伤中的意义。方法:健康成年雄性SD大鼠64只,体重230-310g,随机分成对照组8只和颅脑损伤组56只,颅脑损伤组在外伤后1h、3h、6h、12h、24h、3d、7d处死,每组处死8只。取损伤灶周围的...
两者都是以同源三聚体形式表达;TNF-α和TNF RI和TNF RII结合的亲和力相似,可促进NFκB的激活 。然而,仅有TNF RI具有细胞死亡结构域,能引发细胞凋亡。这两种可溶性受体都被释放到人的血清和尿液中,并能中和TNF-α的活性。 产品信息订购: 产品货号 产品名称 规格 价格 大包装及货期 abs520010 ...
Bcl-2 Activates the Transcription Factor NFκB through the Degradation of the Cytoplasmic Inhibitor IκBα Nuclear factor kappaB (NFkappaB) is a ubiquitously expressed transcription factor that is regulated by the cytoplasmic inhibitor protein IkappaBalpha. Biol... D De Moissac,S Mustapha,AH Greenbe...
adhesion to astrocytes, and that this response was mediated by the inhibition of JNK/ERK1/2/NF-kappa B activation and in the PPAR-independent manner. ... C Jang,J Kim,Y Kwon,... - 《Biomolecules & Therapeutics》 被引量: 0发表: 2020年 Complement Membrane Attack Complexes Assemble NLRP3...
alpha(1) adrenoceptor activation by norepinephrine inhibits LPS-induced cardiomyocyte TNF-alpha production via modulating ERK1/2 and NF-kappa B pathway Furthermore, phenylephrine (PE), an (1)-AR agonist, also suppressed LPS-induced TNF- production. NE inhibited p38 phosphorylation and NF-B activati...
In a similar way NFkappaBi is responsible for a 30% and 70% reduction in TNFalpha gene transcription at 5 and 6 hours, respectively, following treatment with LPS (Figure 1B). Figure 1 Activation of p38 MAP Kinase and NFkappaB pathways regulate LPS induced TNFalpha synthesis from human ...
In some embodiments, the CL comprises the amino acid sequence of a kappa CL or a lambda CL. In some embodiments, the hinge region comprises the amino acid sequence EPKSCDKTHTCPPCP (SEQ ID NO:40). In some embodiments, the CH2 and/or CH3 of the compound (and optionally the CH1 and CL...