综上所述,我们首次发现了介导替加环素耐药的可转移多重耐药RND外排泵基因簇tmexCD1-toprJ1,tmexCD1-toprJ1位于可接合转移IncFIA型质粒上,与位点特异性整合酶相邻.tmexCD1-toprJ1已在鸡源样品中广泛存在,主要由肺炎克雷伯菌携带.尽管tmexCD1-toprJ1在人源菌中检出率较低,但考虑到tmexCD1-toprJ1的可...
Besides that, tigecycline-resistant gene cluster tmexCD1-toprJ1 was also found on the other plasmid which conferred strain resistance to tigecycline. Through epidemiological analysis, we found that the mcr-8 gene has dispersed globally, circulating in the human, animals, and the environment. ...
Importantly, one plasmid was found to co-harbour tmexCD1-toprJ1 and mcr-8.5, which may pose a potential threat to public health. Conclusion:This study demonstrates the clonal dissemination in tmexCD1-toprJ1-carrying K. pneumoniae strains in the chicken farm....
Emergence of Tigecycline and Carbapenem-Resistant Citrobacter freundii Co-Carrying tmexCD1-toprJ1, blaKPC-2, and blaNDM-1 from a Sepsis Patientdoi:10.2147/IDR.S426148blaKPCblaNDMcarbapenem-resistantEnterobacteriaceaetigecycline-resistancetmexCD 1-toprJ 1...
Results: In this work, the natural alkaloid harmaline was found to potentiate tigecycline efficacy (4- to 32-fold) against tmexCD1-toprJ1-positive K. pneumoniae, which also thwarted the evolution of tigecycline resistance. Galleria mellonella and mouse infection models in vivo further revealed ...
tmexCD1-toprJ1Mcr-8.1aac(3’)-IVColistinTigecyclinePurpose This study aimed to characterise the whole-genome structure of two clinical Klebsiella pneumoniae strains co-harbouring mcr-8.1 and tmexCD1-toprJ1, both resistant to colistin and tigecycline.Methods K. pneumoniae strains TGC-02 (ST656)...