TMAO levels are associated to CV-mortality in PAD. Unadjusted cumulative incidence curve for the risk of CV mortality after a competing risk analysis (Fine-Gray model), where the competing event was non-CV death, in all patients categorized according to the TMAO cutoff (>2.26 µmol/L)...
Our aim of the present work is to develop a sensitive, cheap, and reproducible MIP based method that would allow quantification of TMAO at lower quantities (1–15 ppm). Here, we report the first and innovative electrochemical TMAO sensor based on the MIP. The MIP was developed based on the...
However, using LASSO regression model to elucidate the correlation between TMAO and atherosclerosis risk factors, four contributor candidates were successfully identified to have correlation to TMAO levels, including disease status of diabetes or atherosclerosis, and blood lipid indicators level of low-...
We found that plasma TMAO levels in 15 hypertensive patients treated with BBR (0.4 g, tid) were reduced by 8.8 % and 16.7 % at months 1 and 3, respectively, compared with pretreatment baseline. The oral BBR treatment also improved vascular function and lowered blood pressure. ...
Blood biochemistry Participants reported to pathology for a blood test on the morning after completion of the 3WDR, after an overnight fast. Lipids were determined using standard enzymatic techniques (Abbott Architect c16000 assay) by Pathwest, a National Association of Testing Laboratories (NATA) ...
At the end of the diet feeding period, mice were fasted for 4 h before blood and tissue collection. Biochemical assays Plasma TMA, TMAO and creatinine levels were determined by mass spectrometry as previously described2. Indoxyl sulfate was determined by Shimadzu 8050 LC/mass spectrometer by ...
Trimethylamine-N-oxide (TMAO) gained considerable attention because of its role as a cardiovascular risk biomarker. Organic cation transporter 2 (OCT2) mediates TMAO uptake into renal proximal tubular cells. Here we investigated the potential role of mul
Plasma concentrations of d3-γBB, d3-L-carnitine, d3-TMA, and d3-TMAO recovered by sequential venous blood draws were measured using stable isotope dilution LC-MS/MS. p values represent Wilcoxon rank-sum test of the mean of the area under the curve for each replicate mouse (see also ...
reducing TCDCA levels in the liver. This reduction in TCDCA helps to inhibit hepatocyte MPT-Caspase-11 pyroptosis and stellate cell activation, thereby improving liver fibrosis [36].Bacteroides vulgatuscan improve atherosclerosis by lowering blood endotoxin levels and produces N-acetylglucosamine to promote...
1,2,*, Alice Laniepce 3, Shailendra Segobin 1, Céline Boudehent 4, Nicolas Cabé 1,4and Anne Lise Pitel 1 1 Physiopathology and Imaging of Neurological Disorder (PhIND), Cyceron, Institut National de la Santé et de la Recherche Biomédicale (INSERM), Institut Blood and Brain @ Caen...