NF-kappa BTXNIPAMLOvercoming drug resistance is one of key issues in treating refractory acute myeloid leukemia (AML). The Toll-like receptor 4 (TLR4) signaling pathway is involved in many aspects of biological functions of AML cells, including the regulation of pro-inflammatory cytokine products,...
text>Objective: To determine the role of toll-like receptor 4 (TLR4)/nuclear factor kappa B (NF-kappa B) signalling pathway in pulmonary arterial hypertension (PAH) in patients with chronic obstructive pulmonary disease (COPD).Study Design: An experimental study.Place and Duration of Study: Depa...
TLR4 stimulates the transcription factor, nuclear factor kappa B (NFκB), which activates downstream signaling proinflammatory molecules such as cytokines, which include interleukin (IL)-6, 8, 1α, 1β, and tumor necrosis factor (TNF)-α [5]. Leukocyte migration to the affected area is ...
目的:观察热毒宁注射液治疗慢性阻塞性肺疾病急性加重期(AECOPD)的临床疗效及对Toll样受体4(TLR4)/核转录因子κB(NF-κB)炎症信号通路的影响,并探讨其可能作用机制。方法:将72 例AECOPD患者随机分为治疗组和对照组,每组各36 例。对照组采用西医常规治疗,治疗组在
Moreover, HTD4010 down-regulated the expression of TLR4 and NF-κB protein. These results showed that HTD4010 could alleviate the severity of AP possibly by TLR4/NF-κB signaling pathway in HTG-AP.Access through your organization Check access to the full text by signing in through your ...
It has been reported that oxidized low density lipoprotein (oxLDL) inducing formation of foam cells and expression of inflammatory molecules are partly mediated by toll-like receptor 4 (TLR4)/nuclear factor kappa B (NF-κB) pathway. However, whether oxLDL/β2-glycoprotein I/anti-β2-...
Ganglioside GD1a suppresses LPS-induced pro-inflammatory cytokines in RAW264.7 macrophages by reducing MAPKs and NF-kappa B signaling pathways through TLR4 Toll-like receptor 4Nuclear factor-kappa BMitogen-activated protein kinasesAnti-inflammationGangliosides, sialic acid-containing glycosphingolWangShenyang...
coli LPS regulated Th17/Treg balance to mediate the inflammatory responses of OLP through the TLR4/NF-kappa B pathway in vitro, indicating that oral microbiota dysbiosis affected the chronic inflammatory state of OLP.doi:10.1007/s10753-023-01793-7Zhang, Mengna...
TLR4-MyD88-TRAF6-TAK1 Complex-Mediated NF-κB Activation Contribute to the Anti-Inflammatory Effect of V8 in LPS-Induced Human Cervical Cancer SiHa Cells TLR4 - MyD88 - TRAF6 - TAK1 Complex - Mediated NF-资B Activation Contribute to the Anti - Inflammatory Effect of V8 in LPS-Induced ...
TLR4NF-kappa BGestational diabetes mellitus (GDM) is a temporary form of diabetes during pregnancy which influences the health of both mother and child. Both inflammation and oxidative stress have been implicated in the pathophysiology of GDM. Apocynin, acetophenone with anti-oxidative and anti-...