It is suggested that titin constitutes a major component of an elastic, endosarcomeric, superthin filament lattice that coexists with myosin and act in filaments and serves as an organizing template or dynamic scaffold (Wang, 1984).Springer, Boston, MAGassner, DieterUniversity of Bonn...
(vi) What are the substrates for the protein kinase domains of nematode twitchin and insect projectin? If rMLCs are indeed the substrates, how would and why does this phosphorylation take place for the IFM isoform of projectin, which resides primarily in the I band? If rMLCs are the ...
In cardiac muscle, the giant protein titin exists in different length isoforms expressed in the molecule's I-band region. Both isoforms, termed N2-A and N2... WA Linke,DE Rudy,T Centner,... - 《Journal of Cell Biology》 被引量: 449发表: 1999年 Folding and Stretching in a Go-like ...
Background: The giant muscle protein titin forms a filament which spans half of the sarcomere and performs, along its length, quite diverse functions. The region of titin located in the sarcomere I-band is believed to play a major role in extensibility and passive elasticity of muscle. In the...
摘要: Conclusion We suggest that titin Ig domains in the I-band function as extensible components of muscle elasticity by stretching the hinge regions.关键词: Protein Kinases Muscle Proteins Sequence Alignment Magnetic Resonance Spectroscopy Protein Structure, Secondary Protein Structure, Tertiary Molecular...
Large filament proteins in muscle sarcomeres comprise many immunoglobulin-like domains that provide a molecular platform for self-assembly and interactions with heterologous protein partners. We have unravelled the molecular basis for the head-to-tail interaction of the carboxyl terminus of titin and th...
protein foldingGo modelmolecular dynamicstitinThe effect of temperature on mechanical unfolding of proteins is studied using a Go-like model with a realistic contact map and Lennard鈥揓ones contact interactions. The behavior of the I27 domain of titin and its serial repeats is contrasted to that ...
No immunoreaction to this protein was found in the striated and smooth muscles of the mouse. Immunoreaction to titin was only observed in the mouse skeletal muscle, in which both A bands and I bands appeared immunolabeled. Present results show that mini-titin in the invertebrate muscles s...
(2002). Smitin, a novel smooth muscle titin-like protein, interacts with myosin filaments in vivo and in vitro. J. Cell Biol. 156, 101-111.Kim K, Keller III TC. Smitin, a novel smooth muscle titin-like protein, interacts with myosin filaments in vivo and in vitro. J Cell Biol ...
Kettin is a high molecular mass protein of insect muscle associated with thin filaments and alpha-actinin in the Z-disc. It is thought to form a link between thin and thick filaments towards its C-terminus, contributing significantly to passive sarcomere stiffness. Here the elastic properties ...