It is suggested that titin constitutes a major component of an elastic, endosarcomeric, superthin filament lattice that coexists with myosin and act in filaments and serves as an organizing template or dynamic scaffold (Wang, 1984).Springer, Boston, MAGassner, DieterUniversity of Bonn...
Titin的全称即是“Titin”,这一名称来源于希腊语中的“巨人”一词,形象地反映了其巨大的分子尺寸。最初,科学家们曾将其命名为“myosin-like protein”(肌球蛋白样蛋白),因为它与肌球蛋白在结构和功能上有相似之处。然而,随着研究的深入,人们发现Titin与肌球蛋白存在显著差异,因此进行了重新...
Pfuhl M, Pastore A (1995) Tertiary structure of an immunoglobulin-like domain from the giant muscle protein titin:a new member of the I set. Structure 3:391–401 PubMed CAS Google Scholar Improta S, Politou A, Pastore A (1996) Immunoglobulin-like modules from titin I-band:extensible co...
We previously discovered a large titin-like protein—c-titin—in chicken epithelial brush border and human blood platelet extracts that binds α-actinin and organizes arrays of myosin II bipolar filaments in vitro. RT-PCR analysis of total RNA from human megakaryoblastic (CHRF-288-11) and mouse...
microscopically small, titin is gigantic compared to other proteins. Comprised of more than 30,000amino acids, the supersize protein is made from super-repeated structures. The amino acid super-repeats of titin are like tick marks on a yardstick, measuring out uniform sections of the thick ...
Titin is a protein found in certain kind of muscle tissues. It is the thing that makes those muscles elastic. For instance, in heart muscles – that expand and contract continuously for decades, without a break. The folded nature of this huge molecule makes it act like a spring – just ...
Titin, the largest protein known, spans the half-sarcomere (contractile unit of muscle), from Z-disk to M-band9, is modular in structure, and contains ~300 immunoglobulin (Ig)- and fibronectin (Fn)-like domains. The I-band segment of titin contains only Ig domains and several unique sequ...
The genetics and molecular biology of the titin/connectin-like proteins of invertebrates A substantial amount of information has been gathered about the structure and function of twitchin/titin-related proteins in the invertebrates. This has be... GM Benian,A Ayme-Southgate,TL Tinley - 《Reviews...
In the structure, titin is a modular protein with immunoglobulin (Ig)-like domains and fibronectin-domains, especially with unique sequences (N2A and N2B domains) and a segment rich in proline, glutamate, valine, and lysine (PEVK domain) at the elastic I-band (Figure 2a) [63]. The ...
42 However, in the case of a protein the size of titin, how destabilization of a single domain out of hundreds can result in such poisonous consequences is puzzling.7,16,40 This “Achilles heel” effect could stem from different molecular pathways, like induction of full titin degradation as...