Robertson KD, Jones PA. Tissue-specific alternative splicing in the human INK4a/ARF cell cycle regulatory locus. Oncogene . 1999; 18 (26):3810–3820.Robertson K, Jones P (1999) Tissue-specific alternative splicing in the human INK4a/ARF cell cycle regulatory locus. Oncogene 18:3810–3820...
Tissue-specific alternative splicing in the human INK4a/ARF cell cycle regulatory locus 来自 Nature 喜欢 0 阅读量: 22 摘要: The INK4a/ARF locus on human chromosome 9p resides at the nexus of two critical cell cycle regulatory pathways, the p53 pathway and the retinoblastoma (pRb) gene pathw...
Tissue-specific alternative splicing of rat brain fructose 6-phosphate 2-kinase/fructose 2,6-bisphosphatase We have reported the occurrence of eight splice variants of rat brain fructose 6-phosphate 2-kinase/fructose 2,6-bisphosphatase (RB2K). In the present study, we quantified these splice varia...
2023年5月,首都医科大学附属北京胸科医院肿瘤研究中心黄家强教授团队在Acta Pharma Sin B上发表了题为 《UHRF1/DNMT1eMZF1 axis-modulated intragenic site-specific CpGI methylation confers divergent expression and opposing functions of PRSS3 isoforms in lung cancer》[4]的研究论文,探讨了UHRF1/DNMT1–MZ...
Strengths and weaknesses of EST-based prediction of tissue-specific alternative splicing. BMC Genomics. 2004; 5 :72.Gupta S, Zink D, Korn B, Vingron M, Haas SA. Strengths and weaknesses of EST-based prediction of tissue-specific alternative splicing. Bmc Genomics. 2004; 5 :72. doi: ...
可变剪接(Alternative Splicing)是指从一个前体mRNA(pre-mRNA)通过不同的剪接方式(选择不同的剪接位点组合)产生不同的mRNA剪接异构体的过程。这一机制在真核生物中广泛存在,是调节基因表达和产生蛋白质组多样性的重要方式。 基因序列中包含内含子和外显子,通过剪接体(spliceosome)的作用,内含子被移除,外显子被拼接...
1. The transcript of the Na + -Ca 2+ exchanger gene NCX1 undergoes alternative splicing to produce tissue-specific isoforms. The cloned NCX1 isoforms were... A Ruknudin,S He,WJ Lederer,... - 《Journal of Physiology》 被引量: 61发表: 2010年 Signal sequence cleavage and plasma membrane...
We present SpliceTransformer (SpTransformer), a deep-learning framework that predicts tissue-specific RNA splicing alterations linked to human diseases based on genomic sequence. SpTransformer outperforms all previous methods on splicing prediction. Appl
Allele-specific transcript isoforms in human Estimates of the number of human genes that produce more than one transcript isoform through alternative mRNA splicing depend on the assumption that the ob... V Nembaware,KH Wolfe,F Bettoni,... - 《Febs Letters》 被引量: 120发表: 2004年 SpliceNest...
We present SpliceTransformer (SpTransformer), a deep-learning framework that predicts tissue-specific RNA splicing alterations linked to human diseases based on genomic sequence. SpTransformer outperforms all previous methods on splicing prediction. Appl