Generic name of monoclonal antibodyBrand (trade) name(s)Target Alemtuzumab Campath Glycoprotein CD52 Belimumab Benlysta BAFF Bevacizumab Avastin, Mvasi, and Zirabev VEGF-alpha Blinatumomab Blincyto CD19 antigen Cetuximab Erbitux EGFR Daratumumab Darzalex CD38 Denosumab Prolia and Xgeva RANK ligand Dinutuxi...
Gomes-Silva and associates (2017) noted that extending the success of CAR T cells to T cell malignancies is problematic because most target antigens are shared between normal and malignant cells, leading to CAR T cell fratricide. CD7 is a transmembrane protein highly expressed in acute T cell ...
persistence, and target-specific tumor killing, resulting in significantly prolonged survival of the treated animals," said NgocDiep Le, MD, PhD, executive vice president, and chief medical officer, NeoImmuneTech, in the press release. "Now that ...
Clinical TrialTumor TypeTarget AntigenCostimulatory DomainsCombinatorial StrategiesDisease Burden at CAR-T cell InfusionBest Response StatusReported RelapseReferences ChiCTR-OIC-17011272 r/r MM CD19BCMA 41BBCD3ζ NA Relapse or refractory (21/21) CR (12/21)PR (6/21)PD (1/21)SD (1/21)Relapsed...
In short, by partitioning a polymerase chain reaction into large numbers (e.g., 20,000) of individual PCRs, digital PCR uses the limiting dilution principle, where each individual partition either contains the PCR target sequence (“1”) or does not contain it (“0”). As in quantitative...