今年南京DIA QSF会议后,可能在最新版本ICH E9R绿皮书中tipping point analysis出现的频率比较高,接到了组里的一个任务,研究各种终点的临界值分析方法应用(主要用于缺失数据假设的敏感性分析),这也是目前在处理缺失数据时FDA推荐的敏感性分析方法。目前在阅读了大量文献后,已经整理了关于连续型终点和time to event类型终点的tippin
R. Resistant, robust and non-parametric techniques for the analysis of climate data: Theory and examples, including applications to historical radiosonde station data. International Journal of Climatology 61 (1996). 63. Pohlert, T. trend: Non-Parametric Trend Tests and Change-Point Detection, ...
that had a bearing on the potential of parapsychology to revolutionize the sciences in general, and to restructure what we even conceive of as the practice of science to point towards a kind of post paradigmatic, uh, vision for doing science, where theories are understood as models rather than...