Introduction No guideline for time-to-event endpoints (TTEE) definitions in lung cancer trials exists. Areas covered The aim of the study was to evaluate the reporting of TTEE in operable non-small-cell lung cancer randomized clinical trials. Expert opinion Sixty-two TTEE were recorded. In the...
1. Comparing the power of the discontinuation design to that of the classic randomized design on time-to-event endpoints. [J] . Capra WB Controlled clinical trials . 2004,第2期 机译:在事件发生时间终点上,将中断设计的功能与经典随机设计的功能进行比较。 2. Biomarker-Defined Subgroup Selection ...
这些终点通常需要符合"至事件发生时间(time-to-event)"的格式。无进展生存时间(PFS)是大多数实体恶性肿瘤的最佳替代指标… www.ynjr.net|基于3个网页 2. 事件发生的时间 数据分析主要有3种类型:2分法 (dichotomous) 或平均值及标准差(连续变相,continuous) 或追踪事件发生的时间(time-to-even… ...
Design and analysis of clinical trials with time-to-event endpoints Specificity of when an AE occurs (time-to-event) in an RCT is important to note and report. (1) All RCT trials of TNF and COX-2 inhibitors were reviewed for availability of AE reporting, time-to-event data, and other...
Bayesian two-step Lasso strategy for biomarker selection in personalized medicine development for time-to-event endpoints Clinical trial designs for targeted therapy development are progressing toward the goal of personalized medicine. Motivated by the need of ongoing efforts ... X Gu,G Yin,JJ Lee ...
Bayesian two-step Lasso strategy for biomarker selection in personalized medicine development for time-to-event endpoints 来自 Semantic Scholar 喜欢 0 阅读量: 45 作者:X Gu,G Yin,JJ Lee 摘要: Clinical trial designs for targeted therapy development are progressing toward the goal of personalized ...
We investigate the familywise error rate (FWER) for time-to-event endpoints evaluated using a group sequential design with a hierarchical testing procedure for secondary endpoints. We show that, in this setup, the correlation between the log-rank test statistics at interim and at end of study ...
The Average Hazard Ratio - A Good Effect Measure for Time-to-event Endpoints when the Proportional Hazard Assumption is Violated? Background: In many clinical trial applications, the endpoint of interest corresponds to a time-to-event endpoint. In this case, group differences are usua... MKM ...
Response rate, CBR and time-to-event endpoints (PFS and OS) will also be described for patients treated in the 1st versus 2nd and 3rd line setting... C Muttiah,A Travers,JR Whittle,... 被引量: 0发表: 2020年 Impact of lack-of-benefit stopping rules on treatment effect estimates of tw...
The fact that the left endpoints of the lines are staggered refiects that patients usually enter a clinical trial at different calendar times. Timeto-event data from Figure 1.1 available for analysis are the lengths of the patient lines and the event status. This effectively scales event times...