治疗失败时间 time to treatment failure,TTF 定义为:由随机化开始至「退出试验」,退出原因可能是患者拒绝、疾病进展、患者死亡、不良事件等。 由于不单单展现药物疗效,因而不建议用于疗效确认性试验。 TTF 的本质是一具有综合特性的指标,所以,可造成为了达到毒性的降低,而潜在影响了预期疗效的产生。
PAL plus ET was administered to 204 (51%) patients, and 196 (49%) patients received ET only. At the end of the observation, treatment failure occurred in 162 (79%) patients and 183 (93%) patients in both cohorts, due to disease progression (93.2% vs. 96.8%), financial inability (...
Lessons Learned. endpoint was enough time to treatment failure (TTTF) (i.e. radiological and/or symptomatic progression). The secondary endpoints included the tumor response rate (RECIST 1.0) security (National Malignancy Institute Common Terminology Criteria for Adverse Events version 3.0) qualit...
Time to treatment failure (TTF) and overall survival (OS) with palbociclib (PAL) plus endocrine therapy (ET) versus ET in HR+/HER2- advanced breast cancer ... Time to treatment failure (TTF) and overall survival (OS) with palbociclib (PAL) plus endocrine therapy (ET) versus ET in HR+...
aThe primary objective was overall survival (OS) and secondary end points included time to treatment failure (TTF) and the disease control rate (DCR). The chi-square test was used to compare the DCR in patients with and without hyponatremia. OS and TTF were estimated with the Kaplan-Meier ...
May 1, 1999 - Volume 21 - Issue 1 - ppg A24 Articles: PDF Only HAART PROLONGS TIME TO TREATMENT FAILURE (TTF) IN KAPOSI'S SARCOMA (KS).: ABSTRACT 58. Bower, Mark; Fox, Paul; Fife, Kate; Gill, Jas; Nelson, Mark; Gazzard, BrianLogin...
The primary endpoint was the time to treatment failure (TTF). Secondary endpoints included survival, remission rate, toxicity and quality of life. Results : The overall response rate was 75% in the BP and 70% in the MP group. A significantly higher number of patients treated with BP ...
ECOG, Eastern Cooperative Oncology Group; OS, overall survival; PF, progression-free survival; TTF, time to failure of treatment strategy. All statistical analyses were carried out using SPSS version 29 for Windows (IBM, New York, NY, USA). In the univariable analysis, categorical variables were...
Without heat treatment, bearings could not do their job. So by extension - heat treatment keeps the world's wheels turning. Bearings take a variety of forms for different types of jobs. Although we can't discuss them all, here are just a few: babbit, air, magnetic, ball and roller. ...
Brain radiation was considered, however, because the patient’s clinical status rapidly deteriorated, she was not a candidate for other treatment modalities. At 12 weeks from her initial diagnosis she presented to the emergency room in septic shock and passed from respiratory failure two days after...