A previously uncharacterized regulatory module operates selectively at the zonula adherens of epithelial cell junctions, in which positive and negative RhoA regulators are coordinated to fine-tune RhoA activity. Swapnil S. Kher Rebecca A. Worthylake News & Views01 Aug 2012 Nature Cell Biology ...
Nature Reviews Molecular Cell Biology volume 17, pages 564–580 (2016)Cite this article 34k Accesses 48 Altmetric Metrics details Key Points Tight junctions are intercellular adhesion complexes in epithelia and endothelia that control paracellular permeability. This paracellular diffusion barrier is ...
E.Emily Joo,Kenneth M.Yamada, inStem Cell Biology and Tissue Engineering in Dental Sciences, 2015 5.2.2.2Tight Junctions Tight junctionsare located more apically compared to theadherens junctions, and they are regulated by the Par3-Par6-aPKCprotein complex[83,93]. The physical association betwee...
Two recent studies report that ZO proteins, the main scaffolding proteins of tight junctions, undergo liquid phase separation. This new concept provides understanding at the mechanistic level of how tight junctions are formed and how they participate in mechanochemical signaling in early development. ...
In a screen for TβRI binding partners they uncovered Par6, which regulates the assembly of tight junctions — a type of epithelial cell–cell junction — and the apical–basal polarity of epithelial cells. As TGFβ induces tight-junction loss during EMT, the authors delved deeper. They ...
Adachi, M., A. Inoko, M. Hata, K. Furuse, K. Umeda, M. Itoh, and S. Tsukita. 2006. Normal establishment of epithelial tight junctions in mice and cultured cells lacking expression of ZO-3, a tight-junction MAGUK protein.Molecular and Cellular Biology26 (23): 9003–9015. ...
- 《Molecular Biology of the Cell》 被引量: 582发表: 2000年 The structure and regulation of tight junction Tight junctions create a paracellular barrier between both epithelial and endothelial cells. Recent advances have helped define their molecular composition... JM Anderson,MS Balda,AS Fanning ...
Learn more about this topic: Cell Junctions Definition & Types from Chapter 6 / Lesson 12 43K What are cellular junctions? Learn the types of cell junctions, such as tight junctions and the tight junction's function, as well as all cell junction fu...
Cross-talk between tight and anchoring junctions 鈥lesson from the testis. In: Molecular Mechanisms in Spermatogenesis. Cheng, CYT. & T. Clark,Advances in experimental medicine and biology:molecular mechanisms in spermatogenesis. Cheng CY. Landes Bioscience . 2008... H Yan,D Mruk,W Lee,... -...
Tight junctions are one mode of cell–cell adhesion in epithelial and endothelial cellular sheets. They act as a primary barrier to the diffusion of solutes through the intercellular space, create a boundary between the apical and the basolateral plasma membrane domains, and recruit various cytoskelet...