ResearchOpen Access30 Jan 2025 Communications Biology Volume: 8, P: 148 Development of tight junction-strengthening compounds using a high-throughput screening system to evaluate cell surface-localized claudin-1 in keratinocytes Hiroki Sakamoto Momoyo Nishikawa Seigo Yamada ResearchOpen Access09 Feb ...
Cellular biology Nitric oxide regulation of tight junction function in lung epithelial cells UNIVERSITY OF ALASKA ANCHORAGE Cindy Knall BuffoneCindy BNitric oxide (NO) and cigarette smoke are both known to decrease barrier integrity in lung epithelium. The consequence of increased permeability is ...
A non-tight junction function of claudin-7-Interaction with integrin signaling in suppressing lung cancer cell proliferation and detachment. Mol. Cancer 14, 120 (2015). PubMed PubMed Central Google Scholar Dhawan, P. et al. Claudin-1 regulates cellular transformation and metastatic behavior in ...
(Schneeberger and Lynch, 2004; Yamazaki et al., 2008). The associations among claudins and othertight junctional proteinssuch asoccludin, and the cytoplasmic plaqueproteins zona occludens(ZO), regulate tight junction formation, localization, and function (Furuse, 2010). Other proteins, such as...
In addition to the identification of multiple tight junction-associated protein complexes, their morphological appearance, that also gave rise to names such as terminal bar, has led to the perception of tight junctions as static, rigid structures in the plasma membrane, reflecting their function to ...
Wong V. Phosphorylation of occludin correlates with occludin localization and function at the tight junction. Am J Physiol 1997;273(6 Pt 1):C1859–C1867. PubMedCASGoogle Scholar Furuse M, Fujita K, Hiragi T et al. Claudin-1 and-2: Novel integral membrane proteins localising at tight junct...
Tight junctions and intestinal barrier function In the absence of epithelial damage, the tight junction is the rate-limiting determinant of passive paracellular transport. At the tight junction, the intercellular spaces between adjoining cells are eliminated and the outer leaflets of the plasma membrane...
Claudins bind numerous PDZ-containing proteins through their carboxyl termini. As a result, tight junction-strands are thought to have a magnetic bar function, recruiting cytoskeletal and signalling molecules to their cytoplasmic surface, which might contribute to signalling and polarization of the cell....
Tight junction (TJ), an element of epithelial and endothelial junctional complexes, seals cells to create a primary barrier to the diffusion of solutes through the paracellular pathway. TJ is also thought to function as a boundary between the apical and basolateral plasma membrane domains, which ...
tight junction (redirected fromTight junctions) Medical [¦tīt ′jəŋk·shən] (cell and molecular biology) An intercellular junction composed of a series of fusions of the junctional membrane, forming a continuous seal; serves as a selective barrier to small molecules and as a total ...