The thyroid hormones, T3 and T4, exert their target organ effects via nuclearthyroid hormone receptors(TR). After entering target cells, T4 undergoesdeiodinationto T3, which enters the nucleus and binds to TR. Upon T3 binding, the conformation of TR changes, causing the release of ...
Multiple organs are affected by the release of peripheral thyroid hormones (T4 and T3) further regulating various functions at a cellular level. Specifically, skin is considered an important target organ in which the thyroid hormone has a significant impact. Multiple skin dise...
The heart is a major target organ for thyroid hormone action, and marked changes occur in cardiac function in patients with hypothyroidism or hyperthyroidism. Triiodothyronine (T3)-induced changes in cardiac function can result from dire... S Mohr-Kahaly,G Kahaly,J Meyer - 《Zeitschrift Für Ka...
Thyroid hormones include T3 and T4, and the deiodination is a special way to regulate biological activities of thyroid hormones. T4 could transform bioactive T3 in the action of Dio2. In addition, the concentrations and activity of T3 are regulated by iodothyronine deiodinases (Dio2 and Dio3)...
Thyroid Hormone Synthesis and Secretion -- Endotext The main function of the thyroid gland is to make hormones, T4 and T3, which are essential for the regulation of metabolic processes throughout the body. A... LJ De Groot,P Beck-Peccoz,G Chrousos,... - MDText.com, Inc. 被引量: ...
The article presents a case study of abnormal thyroid-stimulating hormone (TSH) secretions in a male patient. The biochemical and radiological investigations diagnosed a TSHoma. These abnormal secretions of TSH are attributed to interfering antibodies to thyroxine (T4), triiodothyrionine (T3), and ...
releasethyroid hormonefrom thyroglobulin. When thyroid hormones are needed, thyroglobulin is reabsorbed from the colloid in the follicular lumen into the cells, where it is split into its component parts, including the two thyroid hormonesthyroxine(T4) andtriiodothyronine(T3). The hormones are then ...
TRH, TSH-releasing hormone; TSH, thyroid-stimulating hormone (thyrotropin); T4, 3,3’,5,5’-tetraiodothyronine (thyroxine, T4); T3, 3,3’,5-triiodothyronine (T3); rT3 3,3’,5’-triiodothyronine (reverse T3, rT3); T2, 3,3’-dioidothyronine; 5’D, deiodination by removal of an ...
T3 Triiodothyronine T4 Thyroxine TPO Thyroid peroxidase TSH Thyroid-stimulating Hormone UDP Uridine diphosphate UDPGA Uridine 5′-diphosphoglucuronic acid UCRM Universal Cryopreservation Recovery Medium UPCM Universal Primary Cell Plating Medium UGT UDP-Glucuronosyl-transferase WTA cells Human embryonic kidney...
In addition, serum free triiodothyronine (FT3) levels can be high-normal to high, free thyroxine (FT4) and reverse T3 (rT3) levels can be normal to low, and the serum thyroid-stimulating hormone (TSH) level is normal or mildly raised. RTH-α cases, particularly those with mild mutations...