Effects of thyroid hormones on the receptor level in estrogen target organs. J Steroid Biochem 29:401-405.Eriksson HA, Freyschuss B. Effects of thyroid hormones on the receptor level in estrogen target organs. J Steroid Biochem. 1988;29:401- 405....
Thyroid hormone (T3) regulates adult intestine development through T3 receptors (TRs). It is difficult to study TR function during postembryonic intestinal maturation in mammals due to maternal influence. We chose intestinal remodeling during Xenopus tropicalis metamorphosis as a model to study TR funct...
Thyroid hormones act at target organs throughout the body to regulate cellular metabolism. T3and T4also feed back at the brain and anterior pituitary gland to regulate levels of TRH and TSH, respectively. The thyroid hormone axis is a classical negative feedback loop, as thyroid hormo...
agonists, GC-1, this compound has the potential to be developed as a new therapeutic agent for the treatment of a variety of metabolic disturbances, including lipid disorders and obesity; thus, it becomes important to determine whether GC-1 has other unknown effects on potential target organs. ...
Similar to PPARs, tissue-dependent distribution of TR isoforms regulates thyroid hormone actions in target organs. Both TRα and TRβ are expressed in virtually all tissues but the abundance varies for each isoform (Lazar 1993). TRα1 is abundantly expressed in the skeletal muscle, heart, and...
With increasing age, the metabolic capacity of elderly individuals decreases, but the thyroid hormone level does not change significantly, which may be due to the decrease in the sensitivity of elderly individual to thyroid hormone [10]. It has been reported that different target organs show ...
immediately by hormone attached to the binding proteins. The binding proteins serve as reservoirs of the two hormones to protect the tissues from sudden surges of thyroid hormone production and probably also tofacilitatedelivery of the hormones to the cells of large, solid organs such as theliver....
Thyroid hormone (triiodothyronine, or T3, and the prohormone thyroxine, or T4) plays a crucial role in the development of the central nervous system. Here we have examined the effects of low T3/T4 levels (hypothyroid status) on the developing rat retina during the perinatal stage. Eyes from ...
Thyroid hormone receptors are expressed in human oocytes, thyroid hormone may affect ovarian function by directly acting on oocytes [22]. In humans, the expression of Thyroid hormone receptors is found to increase with the growth of follicles [22,23]. It was confirmed through in vitro research ...
in “thyroid hormone response elements”, data from TR knockout mice indicate that the different thyroid hormone isoforms have different effects on target organs and genes. These findings provided an impetus to the search for thyroid hormone analogs/agonists that are specific for particu...