Turkish Journal of Endocrinology & MetabolismKale Koroğlu B, Mamanasiry S, Kucuk A, Tamer MN, Yilmaz R, Refetoff S. Resistance to thyroid hormone: Prob- able de novo mutation (P453S) in the receptor beta gene. Turk J Endocrinol Metabol 2009; 13(3):43-6....
Resistance to thyroid hormone (RTH) is an inherited syndrome characterized by reduced tissue responsiveness to thyroid hormone. Subjects have elevated serum thyroid hormone levels in association with a nonsuppressed TSH. Goiter and thyroid test abnormalities have most often led to further investigation, ...
Resistance to thyroid hormone (RTH) is an inherited syndrome of reduced end-organ responsiveness to thyroid hormone (TH). It is characterized by elevated TH levels and nonsupressed serum TSH in the presence of a goiter. As the term implies, subjects with RTH have impaired responsiveness to TH...
Thyroid hormone resistance Other types of thyroiditis (inflammation of the thyroid), such as acute thyroiditis and postpartum thyroiditis Hyperthyroidism Hyperthyroidism describes excessive production of thyroid hormone, a less common condition than hypothyroidism. Symptoms of hypothyroidism usually relate to in...
Resistance to thyroid hormone (RTH) has hitherto been associated with thyroid hormone β receptor (TRβ) mutations which cluster in two regions (αα 310–353 and αα 429–461) of the hor... 查看全部>>doi:10.1016/B978-1-4160-5583-9.00094-0M. Gurnell...
Summary The syndromes of resistance to thyroid hormone (RTH) are rare disorders characterized by elevated levels of circulating free thyroid hormones, inappropriate {TSH} secretion and variably reduced peripheral tissue responses to iodothyronine action. On the basis of clinical features, two major forms...
Resistance to thyroid hormone (RTH), usually caused by an inherited defect of the thyroid hormone receptor, (TRbeta), results in a reduced responsiveness of target tissues to thyroid hormone. Until now, more than 600 cases with RTH have been identified. Although usually linked to the TRbeta ...
Thyroid hormone resistance (RTH) is a rare autosomal dominant disorder, characterized clinically by goiter and biochemically by elevated circulating free thyroid hormone levels in the presence of measurable serum TSH concentrations. About 85% of patients with RTH are harboring mutations in thyroid hormone...
1.Study on TRβ gene mutation in a thyroid hormone resistance syndrome family;甲状腺激素抵抗综合征一家系TRβ基因突变研究 2.Research a case of pituitary thyroid hormone resistance syndrome whose TRβexons\' gene mutation were not found.研究一例未发现TRβ(thyroid hormone receptorβ,TRβ)外显子基...
Background Resistance to thyroid hormone is characterised by a lack of response of peripheral tissues to the active form of thyroid hormone (triiodothyronine, T3). In about 85% of cases, a mutation in THRB, the gene coding for thyroid receptor beta (TR beta), is the cause of this disorder...