Resistance to thyroid hormone (RTH) is usually dominantly inherited and is characterized by elevated free thyroid hormones in the serum and failure to suppress pituitary thyroid stimulating hormone (TSH) secret
Mutations in thyroid hormone receptor α1 (TRα1) cause Resistance to Thyroid Hormone α (RTHα), a disorder characterized by hypothyroidism in TRα1-expressing tissues including the heart. Surprisingly, we report that treatment of RTHα patients with th
Here, we describe the first patients identified with a mutation in THRA that affects both TRα1 and TRα2, and compare them with patients who have resistance to thyroid hormone owing to a mutation affecting only TRα1, to delineate the relative roles of TRα1 and TRα2. Methods We did...
30 GENERALIZED RESISTANCE TO THYROID HORMONE IN A CHILDREN: USE OF PROMOCRIPTINE (BC)Pediatric Research publishes original papers, invited reviews, and commentaries on the etiologies of diseases of children and disorders of development, extending from molecular biology to epidemiology. Use of model ...
Resistance to thyroid hormone syndrome (RTH) is an autosomal dominant or recessive genetic disease caused by mutation of either the thyroid hormone receptorβ (THR-β) gene or the thyroid hormone receptorα (THR-α) gene. RTH due to mutations of the THR-β gene (hereafter, RTH-β) is char...
Resistance to thyroid hormone (RTH), a syndrome of reduced end-organ responsiveness to thyroid hormone (TH), is mostly caused by mutations in the TH receptor (TR) beta gene. Diagnosis is based on persistent elevations of serum free T(4) and often T(3) levels in the absence of TSH ...
网络甲状腺激素不敏感综合征 网络释义 1. 甲状腺激素不敏感综合征 甲状腺激素不敏感综合征(Resistance to Thyroid Hormone) 垂体和周围组织联合不敏感型 ? 选择性外周对甲状腺激素不敏感型 … wenku.baidu.com|基于 1 个网页 例句
S. Refetoff, "The syndrome of generalized resistance to thyroid hormone (GRTH)," Endocrine Research, vol. 15, no. 4, pp. 717- 743, 1989.Refetoff S. The syndrome of generalized resistance to thyroid hormone (GRTH). Endocr Res. 1989;15(4): 717-43....
Resistance to thyroid hormone beta (RTHβ) is a syndrome characterized by reduced responsiveness of peripheral tissues to thyroid hormone (TH). In most cases, the disorder is associated with germline pathogenic variants in the thyroid hormone receptor beta (THRB) gene. This paper summarizes the cli...
《Syndromes of Resistance to Thyroid Hormone Action -Brent》经典培训课件.ppt,TRb TRbK50Q TRbKI46Q TRbK443Q A. TRb Sumoylation Site Mutants Inhibit 3T3L1 Preadipocyte Differentiation Liu et al J Biol Chem 290:7402, 2015 TR Sumoylation Summary Liu et al J