Thyroglobulin type-I-like domains in invariant chain fusion proteins mediate resistance to cathepsin L digestion. FEBS Lett 2000; 485:67-70.Hitzel, C., Kanzler, H., Konig, A., Kummer, M.P., Brix, K., Herzog, V., and Koch, N. (2000). Thyroglobulin type-1-like domains in invariant...
摘要: Production of interleukin-5 and interleukin-10 accompanies T helper celle type 1 (Th1) cytokine responses to a major thyroid self-antigen, thyroglobulin, in health and autoimmune thyroid disease - Syddansk Universitet被引量: 14 年份: 2007 ...
The first transcript, termed “oocyte protease inhibitor-1” (OPI-1), is predicted to encode a 9.1 kDa, 87 amino acid protein containing a single thyroglobulin type-1 (TY) domain, identifying it as a putative TY domain inhibitor. The second transcript, termed OPI-2, is predicted to encode...
The type-1 repeats of thyroglobulin regulate thyroglobulin degradation and T3, T4 release in thyrocytes. FEBS Lett 1996;391:229–231.Molina, F., Pau, B., and Granier, C. (1996). The type-1 repeats of thyroglobulin regulate thyroglobulin degradation and T3, T4 release in thyrocytes. FEBS ...
Individual Recombinant Thyroglobulin Type-1 Domains Are Substrates for Lysosomal Cysteine Proteinases : Biological Chemistry
and we characterize the thyroglobulin type-1 repeat as a protein module The 11 thyroglobulin type-1 repeats possessed the same number of cysteine residues (six in type A, four in the two type B repeats), a fairly constant number of residues between cysteines and a conserved sequence pattern....
Table 2. Characterizationof the thyroglobulin type-1 motifs. Alignment of representative amino acid sequences of thyroglobulin type-1 motifs, consensus sequence and predicted secondary structure. (*) aromatic; (=) hydrophobic. In the prediction, (L) loop ( P > 80%); (E) extended ( P > 80...
Type diabetesWe have previously reported the high levels of glutamic acid decarboxylase 65 autoantibodies (GAD65A) in patients with type 1 diabetes and autoimmune thyroid disease. Here we describe a 32-year-old Japanese female with a thirteen-year history of type 1 diabetes whose levels of GAD...
Kawasaki E, Yasui J, Tsurumaru M, Takashima H, Ikeoka T, Mori F, Akazawa S, Ueki I, Kobayashi M, Kuwahara H et al. Sequential elevation of autoantibodies to thyroglobulin and glutamic acid decarboxylase in type 1 diabetes. World Journal of Diabetes 2013 4 227-230....
Autoimmune thyroid disease Case report Glutamic acid decarboxylase autoantibodies Type 1diabetesWe have previously reported the high levels of glutamic acid decarboxylase 65 autoantibodies(GAD65A)in patients with type 1 diabetes and autoimmune thyroid disease.Here we describe a 32-year-old Japanese female...