Tumor Marker: Thyroglobulin Thyroglobulinis a 670-kD protein dimer of two identical subunits, secreted exclusively bythyroidfollicular cells and differentiatedmalignanciesarising from these cells. As such, after totalthyroidectomyandradioiodineablation of the postsurgical thyroid remnant, it serves as a powerf...
Thus, Tg can be used as a tumor marker only after total thyroidectomy - apart from a few exceptions. In the case of a carcinoma of unknown origin and proven distant metastases which might be thyroid cancer, the level of serum Tg may be a useful indicator. A high Tg value suggests ...
Assessment of the influence of thyroglobulin (Tg) autoantibodies and other interfering factors on the use of serum Tg as tumor marker in differentiated thyroid carcinoma. Thyroid. 1995;5:165–70. Article CAS PubMed Google Scholar Spencer CA. Recoveries cannot be used to authenticate thyroglobulin ...
Given the cellular specificity of thyroglobulin, serum thyroglobulin is a very useful marker of persistent or recurrent tumor in patients after thyroidectomy and ablation of residual normal thyroid tissue. Approximately 60% of differentiated thyroid cancers take up enough iodide to be detected by ...
Thyroid carcinomas are the most common malignant endocrine tumors. Thyroglobulin (Tg), a specific thyroid protein, is the most important tumor marker in thyroid oncology. After total thyroidectomy or radioiodine therapy, detectable or increasing serum Tg levels in patients with differentiated thyroid ...
The sensitivity of the present hTg IRMA system makes it suitable for the measurement of subnormal hTg levels, which is an early and reliable marker of tumor recurrence. Principle of method The technology uses two high affinity monoclonal antibodies in an immunoradiometric assay (IRMA) system. The...
When the washout Tg concentration is high but the cytology negative, it is necessary to identify additional tumor markers that support and enhance diagnostic specificity and sensitivity. Cytokeratin fragment 21-1 (CYFRA 21-1) is a soluble fragment of the cytokeratin 19 protein that serves as a ...
Thyroglobulin as early prognostic marker to predict remission at 18−24 months in differentiated thyroid carcinoma[J]. Clin Endocrinol, 2014, 80(2): 301−306. DOI: 10.1111/cen.12282. [10] Piccardo A, Arecco F, Puntoni M, et al. Focus on High-Risk DTC Patients: High Postoperative ...
Background: Measurement of serum thyroglobulin (Tg) is primarily used as a tumor marker in the postoperative management of patients with differentiated thy... OB Vrndic,S Savin,L Mijatovic,... 被引量: 0发表: 2010年 science corresponding author concentration of thyroglobulin and thyroglobulin- spec...
In such cases, TgAb levels can be adopted as a 'surrogate tumor marker.' Generally, a reduction in serum TgAb concentrations in- dicates that the patient is free from recurrent disease, whereas a clear increase prompts additional investigation to localize the foci of the disease (1). ...