Thyroglobulin is a normal protein produced by thyroid cells, both benign and malignant, and can be used as a tumor marker to detect residual thyroid cells in patients who have undergone thyroidectomy and 131I remnant ablation. AI generated definition based on:Medical Secrets (Fifth Edition),2012 ...
tumor marker testInterfering thyroglobulin antibodies may not always be detected using current methods; recovery tests are an unreliable means to detect interference#Serum thyroglobulin concentrations must be interpreted relative to the mass of thyroid tissue present, any injury effects, the degree of TSH...
Assessment of the influence of thyroglobulin (Tg) autoantibodies and other interfering factors on the use of serum Tg as tumor marker in differentiated thyroid carcinoma. Thyroid. 1995;5:165–70. Article CAS PubMed Google Scholar Spencer CA. Recoveries cannot be used to authenticate thyroglobulin ...
Thyroid carcinomas are the most common malignant endocrine tumors. Thyroglobulin (Tg), a specific thyroid protein, is the most important tumor marker in thyroid oncology. After total thyroidectomy or radioiodine therapy, detectable or increasing serum Tg levels in patients with differentiated thyroid ...
Given the cellular specificity of thyroglobulin, serum thyroglobulin is a very useful marker of persistent or recurrent tumor in patients after thyroidectomy and ablation of residual normal thyroid tissue. Approximately 60% of differentiated thyroid cancers take up enough iodide to be detected by ...
follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a reliable marker to ...
Blood Thyroglobulin levels can be used as a tumor marker for certain kinds of thyroid cancer, and the may also be elevated in cases of Graves' disease. Description Human Thyroglobulin is a biotinylated, glycosylated, polypeptide chain having a total molecular mass of 662 kDa (331 kDa per ...
The sensitivity of the present hTg IRMA system makes it suitable for the measurement of subnormal hTg levels, which is an early and reliable marker of tumor recurrence. Principle of method The technology uses two high affinity monoclonal antibodies in an immunoradiometric assay (IRMA) system. The...
The test's sensitivity might be reduced in cases with minimal tumor tissue or where mutation frequency is under 1%. Quality control of the reagents used in this test was thoroughly verified, and pathologists who are certified confirmed the results. Primary and secondary endpoints The primary ...
In such cases, TgAb levels can be adopted as a 'surrogate tumor marker.' Generally, a reduction in serum TgAb concentrations in- dicates that the patient is free from recurrent disease, whereas a clear increase prompts additional investigation to localize the foci of the disease (1). ...