13,18 Two alternate thyroglobulin assay methods can sometimes circumvent this problem: a traditional 2-antibody immunoassay and liquid chromatography-tandem mass spectrometry.19–21 In patients with thyroglobulin antibodies, serial monitoring of antibody levels in a single assay, can also sometimes be ...
When a high titer antibody is present, an appended comment reflecting the potential for positive or higher than reported Tg can help to ensure that the clinician is not falsely reassured by a low Tg level. 2.4.6.5 Reduction of thyroid hormone replacement doses in patients with thyroid cancer ...
Additionally, a relevant problem in monitoring DTC patients is represented by the presence of thyroglobulin antibody (TgAb). TgAb is present in up to 15–25% of patients with DTC and may interfere on Tg immunoassays resulting in falsely low or undetectable Tg results [4]. In such cases, ...
A serum sample was taken in each trimester for measurement of Tg and Tg antibody (TgAb), in the Regional Laboratory for Endocrinology at the Royal Victoria Hospital Belfast. Both Tg and TgAb were measured using the Electrochemiluminescence immunoassay (ECLIA) on Elecsys and Cobas e immunoassay ana...
Noun 1. antibody - any of a large variety of proteins normally present in the body or produced in response to an antigen which it neutralizes, thus producing an immune response active site - the part of an enzyme or antibody where the chemical reaction occurs protein - any of a large gro...
After HBT treatment, Tg levels dropped to less than 1 ng/ml in 32 specimens (P 56.91%) compared with the original result. There were also two samples that showed a significant increase of greater than 56.91% after HBT treatment. HAB interference is relatively prevalent (1.5-3%) in a ...
Purpose: Postoperative thyroglobulin (Tg) generally serves as a biomarker to monitor the recurrence or persistence of differentiated thyroid cancer (DTC), whereas it constrains to interference from anti-thyroglobulin antibody (TgAb). This study aimed to determine the value of postop...
Phantoms in the Assay Tube: Heterophile Antibody Interferences in Serum Thyroglobulin Assays Get access Carol M. Preissner, Dennis J. O’Kane, Ravinder J. Singh, John C. Morris, Stefan K. G. Grebe The Journal of Clinical Endocrinology & Metabolism, Volume 88, Issue 7, 1 July ...
The greater the amount of the TSHRAb in a sample, the less antibody that was bound by the biotin-conjugated TSHRAb. The tetramethylbenzidine (TMB) solution was added to the wells, and the color developed in contrast to the concentration of the TSHRAb in the sample. Color formation was ...
Just before HI-Rx, preablation Tg, anti-Tg antibody, and TSH were measured. The patients were followed up for a mean period of 7 months (range 6–23 months) by I-123 whole-body scans (f/u IWBS) and stimulated Tg (f/u Tg). Therapeutic failure was defined by positive f/u IWBS ...