Conditions for expressing disease, requirement for intact thymus, and potency estimates of autoimmune lymphocytes in drug-treated rats. These studies explore the phenomenon of cyclosporine-induced autoimmunity in irradiated Lewis rats. We show that (a) the presence of a thymus is required, and ...
autoimmunedisorderceliacthymomathymusThymoma is the most common tumor in the anterior mediastinum. A 56-year-old man presented unremitting and periodic chronic diarrhea of 9 weeks duration, and clinical examination revealed a huge nonhomogeneous mass lesion in the right lung and leukocytosis. He was ...
Hoffacker V, Schultz A, Tiesinga JJ, Gold R, Schalke B, Nix W, Kiefer R, Müller-Hermelink HK, Marx A (2000) Thymomas alter the T-cell subset composition in the blood: a potential mechanism for thymoma-associated autoimmune disease. Blood 96:3872–3879 CASPubMedGoogle Scholar Hollander ...
Myasthenia gravis is an autoimmune disease. An autoantibody directed toward acetylcholine receptor (AChR) causes the destruction of the postsynaptic membrane and a reduction of the number of AChRs at neuromuscular junctions. A very puzzling, but interesting characteristic of myasthenia gravis is that man...
Myasthenia gravis.This autoimmune disease prevents nerves from sending signals to muscles. It makes muscles weak. Pure red cell aplasia.It's a rare blood disorder. Your bone marrow doesn't make enough red blood cells, which leads toanemia. ...
found in myasthenia gravis and, occasionally, in other autoimmune diseases, e.g., Graves disease, rheumatoid arthritis, and systemic lupus erythematosus. Thymomas involve only the thymic epithelial cells. Other tumors, including those associated with Hodgkin's disease and lymphomas, involve thymocytes....
Type 1, or insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease associated with loss of tolerance to several pancreatic islet cell molecules... A Pugliese,M Zeller,A Fernandez,... - 《Nature Genetics》 被引量: 1883发表: 1997年 Tumors of the lung, pleura, thymus and heart Th...
Less common autoimmune diseases related to thymus tumors include Graves’ disease, type 1 diabetes mellitus, and Addison’s disease. When myasthenia gravis is present, patients may have specific types of anti-acetylcholine receptor autoantibodies. Many thymomas do not have autoimmune regulator (AIRE) ...
Development and Function of Diabetogenic T-cells in B-cell鈥揇eficient Nonobese Diabetic Mice Insulin-dependent diabetes(type 1 diabetes)in the NOD mouse is a T-cell-mediated autoimmune disease. However, B-cells may also play a critical role in disease Pathogenesis, as genetically B-cell-deficie...
Immunoglobulin containing cells which were morphologically similar to plasma cells were found in high incidence in autoimmune diseases. At the present time, the author considers that both surface immunoglobulin bearing cells and immunoglobulin containing cells are in the same lineage and immunoglobulin ...