The structure of the thymidine kinase gene promoter: nuclease hypersensitivity correlates with expression. Cell 31:347-353.Sweet, R. W., Chao, M. V., and Axel, R., 1982, The structure of the thymidine kinase gene promoter: Nuclease hypersensitivity correlates with expression, Cell 31 : 347...
In such cases the virus is dependent on the host cells’ thymidine kinase. View chapter Book 1991, Biotechnological Innovations in Health CareOpen universiteit, Thames Polytechnic Related terms: Stem Cell Positron Emission Tomography T Cell Enzyme Cancer Cell Promoter Region Herpes Simplex Virus Human ...
PDX1isoverexpressedinpancreaticcancer,andactivatestheinsulinpromoter(IP).AdenoviralIP– thymidinekinaseandganciclovir(TK/GCV)suppresseshumanpancreaticductalcarcinoma(PDAC)inmice, butrepeateddosescarrysignificanttoxicity.WehypothesizedthatmultiplecyclesofliposomalIP-TK/ GCVablatehumanPDACinSCIDmicewithminimaltoxicityco...
inhibitory activity and mouse tyrosinase and therapeutic genes, namely, HSVtk encoding herpes simplex virus thymidine kinase and FCU1 encoding cytosine deaminase/uracil phosphoribosyltransferase hybrid protein gene, we demonstrated that the promoter strength was not critical for the development of cytotoxic ...
inhibitory activity and mouse tyrosinase and therapeutic genes, namely, HSVtk encoding herpes simplex virus thymidine kinase and FCU1 encoding cytosine deaminase/uracil phosphoribosyltransferase hybrid protein gene, we demonstrated that the promoter strength was not critical for the development of cytotoxic ...
Cytotoxicities of cytosine deaminase and herpes simplex virus thymidine kinase genes in melanoma cells are not affected by the promoter strength 喜欢 0 阅读量: 6 作者: Alekseenko,I.,V.,Kuzmin,D.,V.,Pleshkan,V.,V.,Zinovyeva,M.,V.,Sverdlov,E.,D. 年份: 2013 ...
(2000) Vaccinia as a vector for tumor-directed gene therapy: Biodistribution of a thymidine kinase-deleted mutant. Cancer Gene Ther. 7(1):66-73. Puhlmann, M., et al. (1999) Thymidine Kinase-Deleted Vaccinia Virus Expressing Purine Nucleoside Phosphorylase as a Vector for Tumor-Directed Gene...
A minimum c-erbB-2 promoter-mediated expression of herpes simplex virus thymidine kinase gene confers selective cytotoxicity of human breast cancer cells to ganciclovir[J].Cancer Gene Therapy,2001,(11):890-896.doi:10.1038/sj.cgt.7700389.
A minimum c-erbB-2 promoter- mediated expression of herpes simplex virus thymidine kinase gene confers selective cytotoxicity of human breast cancer cells to ganciclovir. Maeda T,O-Wang J,Matsubara H, et al. Cancer Gene Therapy . 2001Maeda T, O-Wang J, Matsubara H, Asano T, Ochiai T, ...
human thymidine kinase promotercyclin-dependent kinaseTranscriptional activation is important for the elevated expression of human thymidine kinase (hTK) in tumor cells. Here, we used TK(133/+33)-luciferase reporter gene construct and bandshift assay to study the cis -elements involved in ...