Objective: Autosomal recessive human thymidine kinase 2 (TK2) mutations cause TK2 deficiency, which typically manifests as a progressive and fatal mitochondrial myopathy in infants and children. Treatment with pyrimidine deoxynucleosides deoxycytidine and thymidine ameliorates mitochondrial defects and extends...
TK2 is a mitochondrial thymidine kinase 2 that phosphorylates thymidine and deoxycitidine pyrimidine nucleosides to produce their respective monophosphate forms dTMP and dCMP, which are later converted to deoxynucleotide triphosphates (dNTPs). From: Mitochondrion, 2015 ...
TK1 was first found in fetal tissue while TK2 was found in adult tissue and initially they were termed fetal and adult thymidine kinase [5]. After cell division is completed, TK1 is degraded intracellularly, so that it does not pass to body fluids after normal cell division. There is a ...
胸苷酸激酶(Thymidine Kinase 1,TK1)是恶性肿瘤 热度: Deoxycytidine and deoxythymidine treatment for thymidine kinase 2 deficiency.[2017][Ann Neurol][10.1002ana.24922].脱氧胞苷和脱氧胸苷治疗胸苷激酶2缺乏。[2017][安神经] 热度: 血清学胸苷激酶1(TK1) 预示恶性肿瘤风险进程的指标关键词: 胸苷激酶 ... ...
胸苷酸激酶(Thymidine Kinase 1,TK1)是恶性肿瘤 热度: Deoxycytidine and deoxythymidine treatment for thymidine kinase 2 deficiency.[2017][Ann Neurol][10.1002ana.24922].脱氧胞苷和脱氧胸苷治疗胸苷激酶2缺乏。[2017][安神经] 热度: 血清学胸苷激酶1(TK1) 预示恶性肿瘤风险进程的指标关键词: 胸苷激酶 ... ...
In solvent: -80°C for 2 years 溶解度 Ethanol: Soluble DMSO: 44 mg/mL(181.6 mM) Pyridine, Methanol, etc.: Soluble ( < 1 mg/ml refers to the product slightly soluble or insoluble ) 参考文献 1. Sun R , Wang L . Thymidine Kinase 2 Enzyme Kinetics Elucidate the Mechanism of Thymidine...
1 It is phosphorylated by thymidine kinase 2 (TK2) in mitochondria to form deoxythymidine monophosphate .2 Oral administration of thymidine in combination with deoxycytidine increases lifespan in a Tk2 H126N knock-in mouse model of TK2 deficiency. 1.Berg, J.M., Tymoczko, J.L., and Stryer...
Proliferation markers, such as proliferating cell nuclear antigen (PCNA), Ki-67, and thymidine kinase 1 (TK1), have potential as diagnostic tools and as prognostic factors in assessing cancer treatment and disease progression. TK1 is involved in cellular
Substrate-specific deoxycytidine kinase deficiency in 1-B-D-arabinofuranosylcytosine-resistant leukemic cells. Cancer Res., 50 (1990), p. 6515 View in ScopusGoogle Scholar 24 MHN Tattersall, K Ganeshagaru, AV Hoffbrand Mechanisms of resistance of human acute leukemic cells to cytosine arabinoside. ...
The present invention provides isolated nucleic acid molecules encoding a Herpesviridae thymidine kinase enzyme comprising one or more mutations, at least one of the mutations encod